PMID- 23785161
OWN - NLM
STAT- MEDLINE
DCOM- 20130830
LR  - 20211021
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 33
IP  - 25
DP  - 2013 Jun 19
TI  - A critical role for the hippocampus and perirhinal cortex in perceptual learning 
      of scenes and faces: complementary findings from amnesia and FMRI.
PG  - 10490-502
LID - 10.1523/JNEUROSCI.2958-12.2013 [doi]
AB  - It is debated whether subregions within the medial temporal lobe (MTL), in 
      particular the hippocampus (HC) and perirhinal cortex (PrC), play 
      domain-sensitive roles in learning. In the present study, two patients with 
      differing degrees of MTL damage were first exposed to pairs of highly similar 
      scenes, faces, and dot patterns and then asked to make repeated same/different 
      decisions to preexposed and nonexposed (novel) pairs from the three categories 
      (Experiment 1). We measured whether patients would show a benefit of prior 
      exposure (preexposed > nonexposed) and whether repetition of nonexposed (and 
      preexposed) pairs at test would benefit discrimination accuracy. Although 
      selective HC damage impaired learning of scenes, but not faces and dot patterns, 
      broader MTL damage involving the HC and PrC compromised discrimination learning 
      of scenes and faces but left dot pattern learning unaffected. In Experiment 2, a 
      similar task was run in healthy young participants in the MRI scanner. Functional 
      region-of-interest analyses revealed that posterior HC and posterior 
      parahippocampal gyrus showed greater activity during scene pattern learning, but 
      not face and dot pattern learning, whereas PrC, anterior HC, and posterior 
      fusiform gyrus were recruited during discrimination learning for faces, but not 
      scenes and dot pattern learning. Critically, activity in posterior HC and PrC, 
      but not the other functional region-of-interest analyses, was modulated by 
      accuracy (correct > incorrect within a preferred category). Therefore, both 
      approaches revealed a key role for the HC and PrC in discrimination learning, 
      which is consistent with representational accounts in which subregions in these 
      MTL structures store complex spatial and object representations, respectively.
FAU - Mundy, Matthew E
AU  - Mundy ME
AD  - Wales Institute of Cognitive Neuroscience, School of Psychology, Cardiff 
      University, Cardiff CF10 3AT, United Kingdom.
FAU - Downing, Paul E
AU  - Downing PE
FAU - Dwyer, Dominic M
AU  - Dwyer DM
FAU - Honey, Robert C
AU  - Honey RC
FAU - Graham, Kim S
AU  - Graham KS
LA  - eng
GR  - BB/I007091/1/Biotechnology and Biological Sciences Research Council/United 
      Kingdom
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Amnesia/*physiopathology/*psychology
MH  - Carbon Monoxide Poisoning/psychology
MH  - Data Interpretation, Statistical
MH  - Face
MH  - Female
MH  - Hippocampus/*physiopathology
MH  - Humans
MH  - Hypoxia/psychology
MH  - Image Processing, Computer-Assisted
MH  - Learning/*physiology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Parahippocampal Gyrus/physiology/*physiopathology
MH  - Photic Stimulation
MH  - Psychomotor Performance/physiology
MH  - Space Perception/physiology
MH  - Stroke/pathology/psychology
MH  - Temporal Lobe/pathology
MH  - Visual Perception/*physiology
MH  - Young Adult
PMC - PMC3722491
EDAT- 2013/06/21 06:00
MHDA- 2013/08/31 06:00
PMCR- 2013/06/19
CRDT- 2013/06/21 06:00
PHST- 2013/06/21 06:00 [entrez]
PHST- 2013/06/21 06:00 [pubmed]
PHST- 2013/08/31 06:00 [medline]
PHST- 2013/06/19 00:00 [pmc-release]
AID - 33/25/10490 [pii]
AID - 2958-12 [pii]
AID - 10.1523/JNEUROSCI.2958-12.2013 [doi]
PST - ppublish
SO  - J Neurosci. 2013 Jun 19;33(25):10490-502. doi: 10.1523/JNEUROSCI.2958-12.2013.