PMID- 23785672
OWN - NLM
STAT- MEDLINE
DCOM- 20140114
LR  - 20221207
IS  - 2242-3982 (Electronic)
IS  - 1239-9736 (Print)
IS  - 1239-9736 (Linking)
VI  - 72
DP  - 2013
TI  - Genetic polymorphisms in CYP1A1, CYP1B1 and COMT genes in Greenlandic Inuit and 
      Europeans.
PG  - 21113
LID - 10.3402/ijch.v72i0.21113 [doi]
AB  - BACKGROUND: The Indigenous Arctic population is of Asian descent, and their 
      genetic background is different from the Caucasian populations. Relatively little 
      is known about the specific genetic polymorphisms in genes involved in the 
      activation and detoxification mechanisms of environmental contaminants in Inuit 
      and its relation to health risk. The Greenlandic Inuit are highly exposed to 
      legacy persistent organic pollutants (POPs) such as polychlorinated biphenyls 
      (PCBs) and organochlorine pesticides (OCPs), and an elucidation of 
      gene-environment interactions in relation to health risks is needed. OBJECTIVES: 
      The aim of this study was to determine and compare the genotype and allele 
      frequencies of the cytochrome P450 CYP1A1 Ile462Val (rs1048943), CYP1B1 Leu432Val 
      (rs1056836) and catechol-O-methyltransferase COMT Val158Met (rs4680) in 
      Greenlandic Inuit (n=254) and Europeans (n=262) and explore the possible relation 
      between the genotypes and serum levels of POPs. RESULTS: The genotype and allele 
      frequency distributions of the three genetic polymorphisms differed significantly 
      between the Inuit and Europeans. For Inuit, the genotype distribution was more 
      similar to those reported for Asian populations. We observed a significant 
      difference in serum polychlorinated biphenyl (CB-153) and the pesticide 
      1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene (p,p'-DDE) levels between Inuit and 
      Europeans, and for Inuit also associations between the POP levels and genotypes 
      for CYP1A1, CYP1B1 and COMT. CONCLUSION: Our data provide new information on gene 
      polymorphisms in Greenlandic Inuit that might support evaluation of 
      susceptibility to environmental contaminants and warrant further studies.
FAU - Ghisari, Mandana
AU  - Ghisari M
AD  - Centre for Arctic Health and Unit of Cellular and Molecular Toxicology, 
      Department of Public Health, Aarhus University, Denmark.
FAU - Long, Manhai
AU  - Long M
FAU - Bonefeld-Jorgensen, Eva C
AU  - Bonefeld-Jorgensen EC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130617
PL  - United States
TA  - Int J Circumpolar Health
JT  - International journal of circumpolar health
JID - 9713056
RN  - EC 1.14.14.1 (Aryl Hydrocarbon Hydroxylases)
RN  - EC 1.14.14.1 (CYP1B1 protein, human)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP1A1)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP1B1)
RN  - EC 2.1.1.6 (Catechol O-Methyltransferase)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Arctic Regions/epidemiology
MH  - Aryl Hydrocarbon Hydroxylases/*genetics
MH  - Catechol O-Methyltransferase/*genetics
MH  - Cytochrome P-450 CYP1A1/*genetics
MH  - Cytochrome P-450 CYP1B1
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Greenland/epidemiology
MH  - Humans
MH  - Inuit/*genetics
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - White People/*genetics
PMC - PMC3683137
OTO - NOTNLM
OT  - COMT
OT  - Inuit
OT  - PCBs
OT  - cytochrome P450
OT  - genetic polymorphism
OT  - persistent organic pollutants
EDAT- 2013/06/21 06:00
MHDA- 2014/01/15 06:00
PMCR- 2013/01/01
CRDT- 2013/06/21 06:00
PHST- 2013/04/12 00:00 [received]
PHST- 2013/05/13 00:00 [revised]
PHST- 2013/05/13 00:00 [accepted]
PHST- 2013/06/21 06:00 [entrez]
PHST- 2013/06/21 06:00 [pubmed]
PHST- 2014/01/15 06:00 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - 21113 [pii]
AID - 10.3402/ijch.v72i0.21113 [doi]
PST - epublish
SO  - Int J Circumpolar Health. 2013 Jun 17;72:21113. doi: 10.3402/ijch.v72i0.21113. 
      Print 2013.