PMID- 23786433
OWN - NLM
STAT- MEDLINE
DCOM- 20141201
LR  - 20140409
IS  - 1525-6006 (Electronic)
IS  - 1064-1963 (Linking)
VI  - 36
IP  - 3
DP  - 2014
TI  - Echocardiographic assessment of hypertensive patients with or without 
      hyperhomocysteinemia.
PG  - 181-6
LID - 10.3109/10641963.2013.804542 [doi]
AB  - The study was designed to assess left ventricular (LV) systolic and diastolic 
      function in hypertensive patients with or without Hhcy. The study participants 
      consisted of 40 hypertensive patients with Hhcy, 40 hypertensive patients without 
      Hhcy and 40 age-matched healthy control participants. Cardiac functions were 
      determined using echocardiography and the Tei index was calculated for analysis. 
      LAVI (left atrial volume index), IVST (interventricular septum thickness in 
      diastole), PVST (posterior ventricular septum thickness in diastole), LVMI (left 
      ventricular mass index), E/A (peak early and late diastolic transmitral filling 
      flow velocities ratio), DT (deceleration time of the E wave), IRT (isovolumic 
      relaxation time), and the Tei index were different in the hypertensive patient 
      groups (hypertension with Hhcy and hypertension without Hhcy) compared with the 
      controls. The Tei index was significantly higher in the hypertensive groups 
      compared with the controls (0.62 +/- 0.05, 0.51 +/- 0.04, and 0.40 +/- 0.04, 
      respectively, p < 0.01). Significant differences were also observed between the 
      hypertensive patients with Hhcy and the hypertensive patients without Hhcy 
      regarding LAVI (25.6 +/- 4.7 versus 22.9 +/- 3.5 ml/m(2)), E/A (0.73 +/- 0.22 versus 
      0.92 +/- 0.14), DT (93.1 +/- 6.9 versus 84.3 +/- 8.1 ms), IRT (93.1 +/- 6.9 versus 84.3 +/- 
      8.  ms) and the Tei index. Significant correlations were observed between serum 
      homocysteine levels and LV diastolic function parameters (LAVI: r = 0.39, E/A: r 
      = -0.32, DT: r = 0.47, IRT: r = 0.51, p < 0.05). We found that Hhcy had 
      contributory effects on myocardial impairment induced by hypertension. Moreover, 
      there were strong relationships between homocysteine level and LV diastolic 
      dysfunction parameters.
FAU - Zheng, Huan
AU  - Zheng H
AD  - Geriatrics Department, Tongji Hospital affiliated to Tongji University , Shanghai 
      , China .
FAU - Li, Ye
AU  - Li Y
FAU - Xie, Nanzi
AU  - Xie N
FAU - Xu, Huifeng
AU  - Xu H
FAU - Huang, Junling
AU  - Huang J
FAU - Luo, Ming
AU  - Luo M
LA  - eng
PT  - Journal Article
DEP - 20130620
PL  - England
TA  - Clin Exp Hypertens
JT  - Clinical and experimental hypertension (New York, N.Y. : 1993)
JID - 9305929
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - Homocysteinemia
SB  - IM
MH  - Adult
MH  - Aged
MH  - Diastole/physiology
MH  - *Echocardiography/methods
MH  - Female
MH  - Heart Ventricles/physiopathology
MH  - Homocysteine/*blood
MH  - Humans
MH  - Hyperhomocysteinemia/complications/*diagnosis
MH  - Hypertension/complications/*diagnosis/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Ventricular Dysfunction, Left/*physiopathology
MH  - Ventricular Function, Left/*physiology
EDAT- 2013/06/22 06:00
MHDA- 2014/12/15 06:00
CRDT- 2013/06/22 06:00
PHST- 2013/06/22 06:00 [entrez]
PHST- 2013/06/22 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - 10.3109/10641963.2013.804542 [doi]
PST - ppublish
SO  - Clin Exp Hypertens. 2014;36(3):181-6. doi: 10.3109/10641963.2013.804542. Epub 
      2013 Jun 20.