PMID- 23786881
OWN - NLM
STAT- MEDLINE
DCOM- 20140613
LR  - 20221207
IS  - 1873-3360 (Electronic)
IS  - 0306-4530 (Linking)
VI  - 38
IP  - 11
DP  - 2013 Nov
TI  - Altered baseline brain activity in type 2 diabetes: a resting-state fMRI study.
PG  - 2493-501
LID - S0306-4530(13)00189-3 [pii]
LID - 10.1016/j.psyneuen.2013.05.012 [doi]
AB  - PURPOSE: This study aims to investigate whether altered baseline brain activity 
      exists in type 2 diabetes mellitus (T2DM) patients using resting-state functional 
      magnetic resonance imaging (rs-fMRI) and whether abnormal neural activity in the 
      middle temporal gyrus (MTG) is correlated with cognitive function. METHODS: T2DM 
      patients (n=28) were compared with nondiabetic age-, sex-, and education-matched 
      control subjects (n=29) using rs-fMRI. We computed the amplitude of low-frequency 
      fluctuations (ALFF) of fMRI signals to measure spontaneous neuronal activity and 
      detect the relationship between rs-fMRI information and clinical data. RESULTS: 
      Compared with healthy controls, T2DM patients had significantly decreased ALFF 
      values in the bilateral middle temporal gyrus, left fusiform gyrus, left middle 
      occipital gyrus, right inferior occipital gyrus; and increased ALFF values in 
      both the bilateral cerebellum posterior lobe and right cerebellum culmen. 
      Moreover, we found an inverse correlation between the ALFF values in the MTG and 
      both the HbA1c (r=-0.451, p=0.016) and the score of Trail Making Test-B 
      (r=-0.420, p=0.026) in the patient group. On the other hand, C-peptide level and 
      pancreatic beta-cell function had a positive correlation (r=0.429, p=0.023; r=0.453, 
      p=0.016, respectively) with the ALFF value in the middle temporal gyrus. 
      CONCLUSION: The present study confirms that T2DM patients have altered ALFF in 
      many brain regions, which is associated with poor neurocognitive performances, 
      severity of consistent hyperglycemic state and impaired beta-cell function. ALFF 
      disturbance in MTG may play a central role in cognitive decline associated with 
      T2DM and serve as reference for future clinical diagnosis.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Xia, Wenqing
AU  - Xia W
AD  - Medical School of Southeast University, Nanjing, China.
FAU - Wang, Shaohua
AU  - Wang S
FAU - Sun, Zilin
AU  - Sun Z
FAU - Bai, Feng
AU  - Bai F
FAU - Zhou, Yi
AU  - Zhou Y
FAU - Yang, Yue
AU  - Yang Y
FAU - Wang, Pin
AU  - Wang P
FAU - Huang, Yan
AU  - Huang Y
FAU - Yuan, Yang
AU  - Yuan Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130617
PL  - England
TA  - Psychoneuroendocrinology
JT  - Psychoneuroendocrinology
JID - 7612148
RN  - 0 (Blood Glucose)
RN  - 0 (C-Peptide)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
EIN - Psychoneuroendocrinology. 2014 Mar;41:151
MH  - Aged
MH  - Blood Glucose/metabolism
MH  - Brain/*physiopathology
MH  - Brain Mapping
MH  - C-Peptide/blood
MH  - Case-Control Studies
MH  - Cognition Disorders/blood/complications/metabolism/physiopathology/psychology
MH  - Diabetes Mellitus, Type 
      2/blood/complications/metabolism/*physiopathology/*psychology
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Temporal Lobe/physiopathology
OTO - NOTNLM
OT  - Amplitude of low-frequency fluctuations
OT  - Cognitive impairment
OT  - Resting-state fMRI
OT  - T2DM
EDAT- 2013/06/22 06:00
MHDA- 2014/06/15 06:00
CRDT- 2013/06/22 06:00
PHST- 2013/02/19 00:00 [received]
PHST- 2013/05/06 00:00 [revised]
PHST- 2013/05/20 00:00 [accepted]
PHST- 2013/06/22 06:00 [entrez]
PHST- 2013/06/22 06:00 [pubmed]
PHST- 2014/06/15 06:00 [medline]
AID - S0306-4530(13)00189-3 [pii]
AID - 10.1016/j.psyneuen.2013.05.012 [doi]
PST - ppublish
SO  - Psychoneuroendocrinology. 2013 Nov;38(11):2493-501. doi: 
      10.1016/j.psyneuen.2013.05.012. Epub 2013 Jun 17.