PMID- 23788302
OWN - NLM
STAT- MEDLINE
DCOM- 20140808
LR  - 20161125
IS  - 1898-018X (Electronic)
IS  - 1898-018X (Linking)
VI  - 20
IP  - 3
DP  - 2013
TI  - The effect of myocardial fibrosis on left ventricular torsion and twist in 
      patients with non-ischemic dilated cardiomyopathy.
PG  - 276-86
LID - 10.5603/CJ.2013.0073 [doi]
AB  - BACKGROUND: Left ventricular (LV) rotation, twist, and torsion are important 
      aspects of the cardiac performance. Myocardial fibrosis can be identified as the 
      late gadolinium enhancement (LGE) in cardiac magnetic resonance (CMR). In this 
      study, we investigated the association between myocardial fibrosis and LV 
      rotational parameters in patients with nonischemic dilated cardiomyopathy (NDC). 
      METHODS: Twenty-two NDC patients were enrolled. LV dimensions, volumes and 
      ejection fraction (EF) were measured, conventional tissue Doppler imaging data 
      was acquired. Speckle tracking imaging was performed to measure LV deformation, 
      LV rotational parameters. Blood samples were obtained for NT-proBNP. Late 
      gadolinium enhanced cardiac magnetic resonance (LGE-CMR) was used to assess 
      cardiac fibrosis index. RESULTS: Myocardial deformation was similar between LGE+ 
      and LGE- groups. LGE+patients have significantly higher basal and lower apical 
      systolic rotation, lower twist and torsion when compared to LGE- patients. 
      However, untwisting rate was similar between the groups. Torsion was 
      significantly correlated with LVEF and MR-index. Patients with reversed apical 
      systolic rotation had significantly greater NT-proBNP values, basal systolic 
      rotation and significantly lower apical systolic rotation, torsion, and MR-index. 
      CONCLUSIONS: Cardiac fibrosis index is closely related with myocardial torsion 
      and LV systolic function and may be used for the evaluation of cardiac condition. 
      Reversed apical systolicrotation indicated more extensive cardiac fibrosis as it 
      may reflect severe LV dyssynchrony andpoor LV performance.
FAU - Karaahmet, Tansu
AU  - Karaahmet T
AD  - emregurelctf@yahoo.com.
FAU - Gurel, Emre
AU  - Gurel E
FAU - Tigen, Kursat
AU  - Tigen K
FAU - Guler, Ahmet
AU  - Guler A
FAU - Dundar, Cihan
AU  - Dundar C
FAU - Fotbolcu, Hakan
AU  - Fotbolcu H
FAU - Basaran, Yelda
AU  - Basaran Y
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Cardiol J
JT  - Cardiology journal
JID - 101392712
RN  - 0 (Biomarkers)
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 6HG8UB2MUY (Meglumine)
RN  - L0ND3981AG (gadoterate meglumine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - Biomechanical Phenomena
MH  - Cardiomyopathy, Dilated/blood/*complications/pathology/physiopathology
MH  - Contrast Media
MH  - Echocardiography, Doppler
MH  - Female
MH  - Fibrosis
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Meglumine
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Natriuretic Peptide, Brain/blood
MH  - Organometallic Compounds
MH  - Peptide Fragments/blood
MH  - Torsion, Mechanical
MH  - Ventricular Dysfunction, Left/blood/*etiology/pathology/physiopathology
MH  - *Ventricular Function, Left
EDAT- 2013/06/22 06:00
MHDA- 2014/08/13 06:00
CRDT- 2013/06/22 06:00
PHST- 2013/06/10 00:00 [received]
PHST- 2013/06/10 00:00 [accepted]
PHST- 2013/06/22 06:00 [entrez]
PHST- 2013/06/22 06:00 [pubmed]
PHST- 2014/08/13 06:00 [medline]
AID - VM/OJS/J/34821 [pii]
AID - 10.5603/CJ.2013.0073 [doi]
PST - ppublish
SO  - Cardiol J. 2013;20(3):276-86. doi: 10.5603/CJ.2013.0073.