PMID- 23791404 OWN - NLM STAT- MEDLINE DCOM- 20131217 LR - 20211021 IS - 1528-3933 (Electronic) IS - 1091-8531 (Print) IS - 1091-8531 (Linking) VI - 17 IP - 3 DP - 2013 Jun TI - Effects of oxygen on the development and severity of retinopathy of prematurity. PG - 229-34 LID - S1091-8531(13)00133-X [pii] LID - 10.1016/j.jaapos.2012.12.155 [doi] AB - In 1942, when retinopathy of prematurity (ROP) first manifested as retrolental fibroplasia, the technology to monitor or regulate oxygen did not exist, and a fundus examination of preterm infants was not routinely performed. Supplemental, uncontrolled oxygen at birth has since been found to cause retrolental fibroplasia. At the same time, technological advances have made it possible to regulate oxygen and detect early forms of ROP. Nevertheless, despite our better understanding of ROP and ongoing investigations of supplemental therapeutic oxygen, including recent clinical trials (Surfactant, Positive Airway Pressure, Pulse Oximetry Randomized Trial [SUPPORT] and Benefits of Oxygen Saturation Targeting [BOOST]), the best oxygen profiles to reduce ROP risk while optimizing preterm infant health and development remain unknown. This article reviews major studies on oxygen use in preterm infants and the effects on the development of ROP. CI - Copyright (c) 2013 American Association for Pediatric Ophthalmology and Strabismus. Published by Mosby, Inc. All rights reserved. FAU - Hartnett, M Elizabeth AU - Hartnett ME AD - Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA. me.hartnett@hsc.utah.edu FAU - Lane, Robert H AU - Lane RH LA - eng GR - 1R01HL110002-01/HL/NHLBI NIH HHS/United States GR - R01 DK081756/DK/NIDDK NIH HHS/United States GR - R01 HL110002/HL/NHLBI NIH HHS/United States GR - P30 EY014800/EY/NEI NIH HHS/United States GR - R01 EY017011/EY/NEI NIH HHS/United States GR - R01EY017011/EY/NEI NIH HHS/United States GR - R01 EY015130/EY/NEI NIH HHS/United States GR - R01DK080558/DK/NIDDK NIH HHS/United States GR - R01EY015130/EY/NEI NIH HHS/United States GR - R01 DK080558/DK/NIDDK NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Review PL - United States TA - J AAPOS JT - Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus JID - 9710011 RN - S88TT14065 (Oxygen) SB - IM CIN - J AAPOS. 2013 Dec;17(6):650-2. PMID: 24200805 CIN - J AAPOS. 2013 Dec;17(6):652. PMID: 24215804 MH - Bronchopulmonary Dysplasia/therapy MH - Humans MH - Infant, Low Birth Weight MH - Infant, Newborn MH - Infant, Premature/blood MH - Oxygen/*administration & dosage/blood MH - Oxygen Inhalation Therapy/*adverse effects MH - Respiratory Distress Syndrome, Newborn/therapy MH - Retinopathy of Prematurity/*etiology/*prevention & control PMC - PMC3740273 MID - NIHMS487275 EDAT- 2013/06/26 06:00 MHDA- 2013/12/18 06:00 PMCR- 2014/06/01 CRDT- 2013/06/25 06:00 PHST- 2012/10/12 00:00 [received] PHST- 2012/12/18 00:00 [revised] PHST- 2012/12/30 00:00 [accepted] PHST- 2013/06/25 06:00 [entrez] PHST- 2013/06/26 06:00 [pubmed] PHST- 2013/12/18 06:00 [medline] PHST- 2014/06/01 00:00 [pmc-release] AID - S1091-8531(13)00133-X [pii] AID - 10.1016/j.jaapos.2012.12.155 [doi] PST - ppublish SO - J AAPOS. 2013 Jun;17(3):229-34. doi: 10.1016/j.jaapos.2012.12.155.