PMID- 23792305
OWN - NLM
STAT- MEDLINE
DCOM- 20140401
LR  - 20190318
IS  - 1538-9235 (Electronic)
IS  - 1040-5488 (Linking)
VI  - 90
IP  - 7
DP  - 2013 Jul
TI  - Combined effect of comfort and adverse events on contact lens performance.
PG  - 674-81
LID - 10.1097/OPX.0000000000000008 [doi]
AB  - PURPOSE: To report the performance of various contact lenses and lens care 
      solution combinations based on the combined response of subjective comfort and 
      adverse events (AEs). METHODS: A retrospective analysis of 28 lens/solution 
      combinations each tested on approximately 40 participants who wore their assigned 
      combination on a daily wear basis and were followed for a 3-month period, with 
      visits at baseline, 2 weeks, and 1 and 3 months. Lenses included frequent 
      replacement and daily disposables. Solutions included hydrogen peroxide and 
      multipurpose types. Subjective comfort (scale of 1 to 10) and AEs were collected 
      and reported as a group mean and percentage, respectively. The data were 
      converted into a ratio between 0 and 1 to represent the relative performance 
      within the combination series, with a higher ratio indicating better performance 
      in both AE rates and comfort. RESULTS: The overall AE rate was 3.6 events per 100 
      participant-months (95% confidence interval [95% CI], 2.7 to 4.7%). The rate was 
      found to be lower in daily disposables compared with that in daily wear lenses 
      (3.1 vs. 10.9%, p < 0.001). The overall comfort on insertion rating was 8.3 (95% 
      CI, 8.1 to 8.4), and comfort at end of day was 7.2 (95% CI, 7.0 to 7.4). Based on 
      the 28 lens/solution combinations, there was no significant correlation between 
      overall AE rates and comfort on insertion or at end of day (Pearson correlation, 
      -0.34, p = 0.08; and Pearson correlation, -0.23, p = 0.25, respectively). Less 
      than 18% of the combinations tested combined good comfort with low AE rates. 
      CONCLUSIONS: Both subjective comfort responses and AE rates varied according to 
      the combination of lens type and care system in use. The combinations with the 
      best comfort ratings did not necessarily have a favorable AE rate. Practitioners 
      can maximize behavior with respect to both these factors by choosing an 
      appropriate care system for the lenses they prescribe.
FAU - Diec, Jennie
AU  - Diec J
AD  - Brien Holden Vision Institute, University of New South Wales, Sydney, NSW 2052, 
      Australia.
FAU - Papas, Eric
AU  - Papas E
FAU - Naduvilath, Thomas
AU  - Naduvilath T
FAU - Xu, Pauline
AU  - Xu P
FAU - Holden, Brien A
AU  - Holden BA
FAU - Lazon de la Jara, Percy
AU  - Lazon de la Jara P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Optom Vis Sci
JT  - Optometry and vision science : official publication of the American Academy of 
      Optometry
JID - 8904931
RN  - 0 (Contact Lens Solutions)
SB  - IM
MH  - *Contact Lens Solutions/adverse effects
MH  - *Contact Lenses, Hydrophilic/adverse effects
MH  - Cornea/*physiology
MH  - Disposable Equipment
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Patient Satisfaction
MH  - Prosthesis Fitting
MH  - Refractive Errors/physiopathology/*therapy
MH  - Retrospective Studies
MH  - Visual Acuity/*physiology
EDAT- 2013/06/26 06:00
MHDA- 2014/04/02 06:00
CRDT- 2013/06/25 06:00
PHST- 2013/06/25 06:00 [entrez]
PHST- 2013/06/26 06:00 [pubmed]
PHST- 2014/04/02 06:00 [medline]
AID - 00006324-201307000-00009 [pii]
AID - 10.1097/OPX.0000000000000008 [doi]
PST - ppublish
SO  - Optom Vis Sci. 2013 Jul;90(7):674-81. doi: 10.1097/OPX.0000000000000008.