PMID- 23793776
OWN - NLM
STAT- MEDLINE
DCOM- 20140410
LR  - 20211021
IS  - 1867-108X (Electronic)
IS  - 1867-1071 (Linking)
VI  - 31
IP  - 8
DP  - 2013 Aug
TI  - Volumetric low-tube-voltage CT imaging for evaluating hypervascular 
      hepatocellular carcinoma; effects on radiation exposure, image quality, and 
      diagnostic performance.
PG  - 521-9
LID - 10.1007/s11604-013-0217-5 [doi]
AB  - OBJECTIVES: To assess the value of hepatic arterial-phase (HAP) imaging with a 
      low tube voltage (80 kVp), using non-helical, volumetric acquisition with a 
      320-detector-rows area-detector CT (ADCT) scanner for evaluating hypervascular 
      hepatocellular carcinoma (HCC) compared with routine 120-kVp HAP imaging. 
      METHODS: This study enrolled 128 patients with 148 HCCs. Seventy-six patients 
      with 79 HCCs underwent HAP imaging with 80 kVp obtained using a 320-detector-rows 
      ADCT scanner. The remaining 52 patients with 69 HCCs underwent routine HAP 
      imaging with 120 kVp obtained by 64-slice helical acquisition. Image noise and 
      tumor to liver contrast-to-noise ratio (CNR) of the two sets of images were 
      compared. Three radiologists evaluated both sets of images using receiver 
      operating characteristic analyses. RESULTS: Although there was a two-fold 
      increase in the mean image noise with 80 kVp over that with 120 kVp (p < 0.001), 
      no significant differences were observed in CNR among the two sets. The mean area 
      under the curve (Az value) and the sensitivity for detecting HCC with 80 kVp 
      (0.980, 78/79, respectively) were higher than that of 120 kVp (0.892, 55/69, 
      respectively). CONCLUSIONS: HAP imaging with 80 kVp obtained by an ADCT scanner 
      significantly improves the diagnostic performance for evaluating hypervascular 
      HCC.
FAU - Ichikawa, Tomoaki
AU  - Ichikawa T
AD  - Department of Radiology, University of Yamanashi, 1110 Shimokato, Chuo, 
      Yamanashi, Japan. ichikawa@yamanashi.ac.jp
FAU - Motosugi, Utaroh
AU  - Motosugi U
FAU - Morisaka, Hiroyuki
AU  - Morisaka H
FAU - Sano, Katsuhiro
AU  - Sano K
FAU - Ali, Muhi
AU  - Ali M
FAU - Araki, Tsutomu
AU  - Araki T
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20130622
PL  - Japan
TA  - Jpn J Radiol
JT  - Japanese journal of radiology
JID - 101490689
RN  - 0 (Contrast Media)
RN  - 4419T9MX03 (Iohexol)
SB  - IM
MH  - Aged
MH  - Carcinoma, Hepatocellular/*diagnostic imaging
MH  - Contrast Media
MH  - Female
MH  - Humans
MH  - Iohexol
MH  - Liver/diagnostic imaging
MH  - Liver Neoplasms/*diagnostic imaging
MH  - Male
MH  - Middle Aged
MH  - Observer Variation
MH  - Prospective Studies
MH  - ROC Curve
MH  - *Radiation Dosage
MH  - Radiographic Image Enhancement/methods
MH  - Radiographic Image Interpretation, Computer-Assisted/methods
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Tomography, Spiral Computed/methods
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2013/06/25 06:00
MHDA- 2014/04/11 06:00
CRDT- 2013/06/25 06:00
PHST- 2013/01/11 00:00 [received]
PHST- 2013/05/10 00:00 [accepted]
PHST- 2013/06/25 06:00 [entrez]
PHST- 2013/06/25 06:00 [pubmed]
PHST- 2014/04/11 06:00 [medline]
AID - 10.1007/s11604-013-0217-5 [doi]
PST - ppublish
SO  - Jpn J Radiol. 2013 Aug;31(8):521-9. doi: 10.1007/s11604-013-0217-5. Epub 2013 Jun 
      22.