PMID- 23794112
OWN - NLM
STAT- MEDLINE
DCOM- 20140221
LR  - 20221207
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 34
IP  - 6
DP  - 2013 Dec
TI  - The -137G>C polymorphism in interleukin-18 promoter region and cancer risk: 
      evidence from a meta-analysis of 21 studies.
PG  - 3483-90
LID - 10.1007/s13277-013-0926-5 [doi]
AB  - Interleukin-18 (IL-18) is a key cytokine responsible for immune response and 
      involved in the process of cancer development. The association of -137G>C 
      polymorphism in the promoter region of IL-18 with cancer risk is still elusive 
      based on current genetic association studies. We performed this meta-analysis to 
      determine whether the -137G>C polymorphism is associated with cancer risk. A 
      comprehensive search was conducted for databases of PubMed, EMBASE, and China 
      National Knowledge Infrastructure. Pooled odds ratios (ORs) and 95% confidence 
      intervals (CIs) were calculated to estimate the association strength. Publication 
      bias was detected by Egger's and Begg's test. Twenty-one eligible studies 
      including 3,498 cancer patients and 5,222 controls were identified and analyzed. 
      In the overall analysis, no significant association between -137G>C polymorphism 
      and cancer risk was observed. In the sub-group analyses of ethnicities, the 
      -137G>C polymorphism significantly increased cancer risk in Asian population 
      (GC/CC vs. GG: OR = 1.313, 95% CI = 1.053-1.638, heterogeneity P < 0.001) but not 
      in Caucasian population. Further stratified analyses showed that the variant 
      -137C allele was significantly associated with increased risk of nasopharyngeal 
      carcinoma (C vs. G: OR = 1.484, 95% CI = 1.193-1.847, heterogeneity P = 0.213). 
      No publication bias was detected. We provide evidence that the -137G>C 
      polymorphism in IL-18 promoter region significantly increases cancer risk in 
      Asian population but not in Caucasian population, and the variant -137C allele is 
      associated with increased risk of nasopharyngeal carcinoma.
FAU - Liang, Tie-Jun
AU  - Liang TJ
AD  - Department of Digestive Diseases, Provincial Hospital affiliated to Shandong 
      University, Jinan, 250021, People's Republic of China.
FAU - Ma, Hui
AU  - Ma H
FAU - Wang, Cong-Xiao
AU  - Wang CX
FAU - Liu, Yin-Rong
AU  - Liu YR
FAU - Wang, Xing-Guo
AU  - Wang XG
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20130622
PL  - Netherlands
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental 
      Biology and Medicine
JID - 8409922
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People/genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/ethnology/*genetics
MH  - Genotype
MH  - Humans
MH  - Interleukin-18/*genetics
MH  - Male
MH  - Middle Aged
MH  - Nasopharyngeal Neoplasms/ethnology/genetics
MH  - Neoplasms/ethnology/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic/*genetics
MH  - Risk Factors
MH  - White People/genetics
MH  - Young Adult
EDAT- 2013/06/25 06:00
MHDA- 2014/02/22 06:00
CRDT- 2013/06/25 06:00
PHST- 2013/04/27 00:00 [received]
PHST- 2013/06/11 00:00 [accepted]
PHST- 2013/06/25 06:00 [entrez]
PHST- 2013/06/25 06:00 [pubmed]
PHST- 2014/02/22 06:00 [medline]
AID - 10.1007/s13277-013-0926-5 [doi]
PST - ppublish
SO  - Tumour Biol. 2013 Dec;34(6):3483-90. doi: 10.1007/s13277-013-0926-5. Epub 2013 
      Jun 22.