PMID- 23794736
OWN - NLM
STAT- MEDLINE
DCOM- 20131021
LR  - 20220321
IS  - 1758-0463 (Electronic)
IS  - 1758-0463 (Linking)
VI  - 2013
DP  - 2013
TI  - ESCAPE: database for integrating high-content published data collected from human 
      and mouse embryonic stem cells.
PG  - bat045
LID - 10.1093/database/bat045 [doi]
LID - bat045
AB  - High content studies that profile mouse and human embryonic stem cells (m/hESCs) 
      using various genome-wide technologies such as transcriptomics and proteomics are 
      constantly being published. However, efforts to integrate such data to obtain a 
      global view of the molecular circuitry in m/hESCs are lagging behind. Here, we 
      present an m/hESC-centered database called Embryonic Stem Cell Atlas from 
      Pluripotency Evidence integrating data from many recent diverse high-throughput 
      studies including chromatin immunoprecipitation followed by deep sequencing, 
      genome-wide inhibitory RNA screens, gene expression microarrays or RNA-seq after 
      knockdown (KD) or overexpression of critical factors, immunoprecipitation 
      followed by mass spectrometry proteomics and phosphoproteomics. The database 
      provides web-based interactive search and visualization tools that can be used to 
      build subnetworks and to identify known and novel regulatory interactions across 
      various regulatory layers. The web-interface also includes tools to predict the 
      effects of combinatorial KDs by additive effects controlled by sliders, or 
      through simulation software implemented in MATLAB. Overall, the Embryonic Stem 
      Cell Atlas from Pluripotency Evidence database is a comprehensive resource for 
      the stem cell systems biology community. Database URL: 
      http://www.maayanlab.net/ESCAPE
FAU - Xu, Huilei
AU  - Xu H
AD  - Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at 
      Mount Sinai, One Gustave L. Levy Place, Box 1215, New York, NY 10029, USA.
FAU - Baroukh, Caroline
AU  - Baroukh C
FAU - Dannenfelser, Ruth
AU  - Dannenfelser R
FAU - Chen, Edward Y
AU  - Chen EY
FAU - Tan, Christopher M
AU  - Tan CM
FAU - Kou, Yan
AU  - Kou Y
FAU - Kim, Yujin E
AU  - Kim YE
FAU - Lemischka, Ihor R
AU  - Lemischka IR
FAU - Ma'ayan, Avi
AU  - Ma'ayan A
LA  - eng
GR  - RC1GM091176-01/GM/NIGMS NIH HHS/United States
GR  - R01GM078465-03/GM/NIGMS NIH HHS/United States
GR  - R01 GM098316/GM/NIGMS NIH HHS/United States
GR  - R01DK088541-01A1/DK/NIDDK NIH HHS/United States
GR  - P50GM071558-03/GM/NIGMS NIH HHS/United States
GR  - P50 GM071558/GM/NIGMS NIH HHS/United States
GR  - R01GM098316-01A1/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20130621
PL  - England
TA  - Database (Oxford)
JT  - Database : the journal of biological databases and curation
JID - 101517697
RN  - 0 (Biomarkers)
SB  - IM
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Cell Lineage
MH  - *Databases as Topic
MH  - Embryonic Stem Cells/cytology/*metabolism
MH  - High-Throughput Screening Assays
MH  - Humans
MH  - Mice
MH  - Pluripotent Stem Cells/cytology/metabolism
MH  - *Publications
MH  - Search Engine
PMC - PMC3689438
EDAT- 2013/06/26 06:00
MHDA- 2013/10/22 06:00
PMCR- 2013/06/21
CRDT- 2013/06/25 06:00
PHST- 2013/06/25 06:00 [entrez]
PHST- 2013/06/26 06:00 [pubmed]
PHST- 2013/10/22 06:00 [medline]
PHST- 2013/06/21 00:00 [pmc-release]
AID - bat045 [pii]
AID - 10.1093/database/bat045 [doi]
PST - epublish
SO  - Database (Oxford). 2013 Jun 21;2013:bat045. doi: 10.1093/database/bat045. Print 
      2013.