PMID- 23795643
OWN - NLM
STAT- MEDLINE
DCOM- 20140224
LR  - 20130809
IS  - 1462-5822 (Electronic)
IS  - 1462-5814 (Linking)
VI  - 15
IP  - 9
DP  - 2013 Sep
TI  - Serving the new masters - dendritic cells as hosts for stealth intracellular 
      bacteria.
PG  - 1473-83
LID - 10.1111/cmi.12160 [doi]
AB  - Dendritic cells (DCs) serve as the primers of adaptive immunity, which is 
      indispensable for the control of the majority of infections. Interestingly, some 
      pathogenic intracellular bacteria can subvert DC function and gain the advantage 
      of an ineffective host immune reaction. This scenario appears to be the case 
      particularly with so-called stealth pathogens, which are the causative agents of 
      several under-diagnosed chronic diseases. However, there is no consensus how less 
      explored stealth bacteria like Coxiella, Brucella and Francisella cross-talk with 
      DCs. Therefore, the aim of this review was to explore the issue and to summarize 
      the current knowledge regarding the interaction of above mentioned pathogens with 
      DCs as crucial hosts from an infection strategy view. Evidence indicates that 
      infected DCs are not sufficiently activated, do not undergo maturation and do not 
      produce expected proinflammatory cytokines. In some cases, the infected DCs even 
      display immunosuppressive behaviour that may be directly linked to the induction 
      of tolerogenicity favouring pathogen survival and persistence.
CI  - (c) 2013 John Wiley & Sons Ltd.
FAU - Fabrik, Ivo
AU  - Fabrik I
AD  - Institute of Molecular Pathology, Faculty of Military Health Sciences, University 
      of Defence, Hradec Kralove, Czech Republic. fabrik@pmfhk.cz
FAU - Hartlova, Anetta
AU  - Hartlova A
FAU - Rehulka, Pavel
AU  - Rehulka P
FAU - Stulik, Jiri
AU  - Stulik J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130729
PL  - India
TA  - Cell Microbiol
JT  - Cellular microbiology
JID - 100883691
SB  - IM
MH  - Animals
MH  - Brucella/immunology/*physiology
MH  - Coxiella/immunology/*physiology
MH  - Dendritic Cells/*immunology/*microbiology
MH  - Francisella/immunology/*physiology
MH  - *Host-Pathogen Interactions
MH  - Humans
MH  - Immune Evasion
MH  - Immune Tolerance
EDAT- 2013/06/26 06:00
MHDA- 2014/02/25 06:00
CRDT- 2013/06/26 06:00
PHST- 2013/03/06 00:00 [received]
PHST- 2013/05/14 00:00 [revised]
PHST- 2013/05/23 00:00 [accepted]
PHST- 2013/06/26 06:00 [entrez]
PHST- 2013/06/26 06:00 [pubmed]
PHST- 2014/02/25 06:00 [medline]
AID - 10.1111/cmi.12160 [doi]
PST - ppublish
SO  - Cell Microbiol. 2013 Sep;15(9):1473-83. doi: 10.1111/cmi.12160. Epub 2013 Jul 29.