PMID- 23796219
OWN - NLM
STAT- MEDLINE
DCOM- 20130826
LR  - 20191112
IS  - 1521-9437 (Print)
IS  - 1940-4344 (Linking)
VI  - 15
IP  - 4
DP  - 2013
TI  - MT-alpha-glucan from the fruit body of the maitake medicinal mushroom Grifola 
      frondosa (higher Basidiomyetes) shows protective effects for hypoglycemic 
      pancreatic beta-cells.
PG  - 373-81
AB  - The hypoglycemic effect of an alpha-glucan (designated here as MT-alpha-glucan) from the 
      fruit body of the Maitake medicinal mushroom, Grifola frondosa, on a murine type 
      2 diabetes mellitus (T2DM) model was evaluated. Body weight and levels of fasting 
      plasma glucose, glycosylated hemoglobin, triglycerides, cholesterol, free fatty 
      acid, nitric oxide (NO), NO synthase, inducible NO synthase, and hepatic 
      malondialdehyde content decreased significantly when MT-alpha-glucan was administered 
      to T2DM mice. The content of serum insulin, hepatic glycogen, and reduced 
      glutathione and the activity of superoxide dismutase and glutathione peroxidase 
      increased significantly when MT-alpha-glucan was administered to T2DM mice. 
      Histopathological changes of the pancreas were ameliorated in the treatment 
      group. These data suggest that MT-alpha-glucan has a hypoglycemic effect on T2DM 
      mice, which might be related to its protective effect of pancreatic beta-cells 
      exerted by decreasing levels of factors that destroy beta-cells, such as oxidative 
      stress and NO synthesis.
FAU - Lei, Hong
AU  - Lei H
AD  - Department of Biological Science, Hefei University of Technology, Hefei, China. 
      leihong56@163.com
FAU - Zhang, Minmin
AU  - Zhang M
FAU - Wang, Qin
AU  - Wang Q
FAU - Guo, Shuzhen
AU  - Guo S
FAU - Han, Juncheng
AU  - Han J
FAU - Sun, Hanju
AU  - Sun H
FAU - Wu, Wutong
AU  - Wu W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Med Mushrooms
JT  - International journal of medicinal mushrooms
JID - 100886202
RN  - 0 (Lipids)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 2.5.1.18 (Glutathione Transferase)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Animals
MH  - Fruiting Bodies, Fungal/*chemistry
MH  - Gene Expression Regulation
MH  - Glutathione
MH  - Glutathione Transferase/genetics/metabolism
MH  - Grifola/*chemistry
MH  - Hypoglycemia/*pathology
MH  - Insulin-Secreting Cells/*drug effects
MH  - Lipids/blood
MH  - Male
MH  - Malondialdehyde
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Superoxide Dismutase
EDAT- 2013/06/26 06:00
MHDA- 2013/08/27 06:00
CRDT- 2013/06/26 06:00
PHST- 2013/06/26 06:00 [entrez]
PHST- 2013/06/26 06:00 [pubmed]
PHST- 2013/08/27 06:00 [medline]
AID - 3eefb46658ba8153,571334a756c72390 [pii]
AID - 10.1615/intjmedmushr.v15.i4.50 [doi]
PST - ppublish
SO  - Int J Med Mushrooms. 2013;15(4):373-81. doi: 10.1615/intjmedmushr.v15.i4.50.