PMID- 23797433
OWN - NLM
STAT- MEDLINE
DCOM- 20131101
LR  - 20140129
IS  - 1897-4279 (Electronic)
IS  - 0022-9032 (Linking)
VI  - 71
IP  - 6
DP  - 2013
TI  - Correlation between clinical parameters of periodontal disease and mean platelet 
      volume in patients with coronary artery disease: a pilot study.
PG  - 600-5
LID - 10.5603/KP.2013.0124 [doi]
AB  - BACKGROUND: Cardiovascular diseases as well as periodontitis can be regarded as 
      current epidemics and have become a social problem. Mean platelet volume (MPV) is 
      a simple, routinely assessed biochemical parameter, which is becoming regarded 
      asa new, independent risk factor of acute coronary syndromes and stroke. AIM: 
      Assessment of a potential relationship between clinical indices of periodontal 
      disease and MPV in relation to the presence of coronary artery disease (CAD) and 
      chronic periodontitis. METHODS: The study included 57 individuals aged from 50 to 
      65 years. Patients were divided into three groups. Group 1 consisted of 19 
      patients with previously diagnosed CAD and coexisting chronic periodontitis. 
      Group 2 included 18 patients with diagnosed chronic periodontitis with excluded 
      CAD. Group 3 was a control group and consisted of 20 healthy individuals without 
      CAD or periodontitis. RESULTS: Unsatisfactory oral hygiene defined by plaque 
      index (PI) was observed in all patients. Mean PI was significantly higher in 
      Groups 1 and 2 than in Group 3 (76.7% vs. 45.7%, p < 0.01). Mean bleeding index 
      (BI) was significantly higher in Group 2 than in Groups 1 and 3 (46.4% vs. 29.8%, 
      p < 0.05). Mean periodontal pocket depths (PD) (2.75 mm, 2.93 mm,1.97 mm, 
      respectively, p < 0.05, p < 0.01) and clinical attachment loss (CAL) were 
      significantly higher in Groups 1 and 2 than in Group 3 (5.13 mm, 4.79 mm, 1.31 
      mm, respectively, p < 0.01). Mean WBC, fibrinogen and hsCRP were not 
      significantly different among the examined groups (WBC 6.81 G/L vs. 6.71 G/L vs. 
      6.18 G/L, fibrinogen concentration 4.31 g/L vs. 3.94 g/L vs. 3.67 g/L; hsCRP 
      concentration 4.08 mg/dL vs. 6.61 mg/dL vs. 4.33 mg/dL). In Group 1, MPV was 
      significantly higher than in Group 3 (10.39 fL vs. 9.39 fL, p < 0.01). There was 
      a weak, although significant, correlation between periodontal parameters and MPV 
      and correlations between MPV and PD as well as CAL (MPV-PD: r = 0.45, p < 0.05; 
      MPV-CAL: r = 0.42, p < 0.05). CONCLUSIONS: Chronic periodontitis in patients with 
      CAD results in an increased MPV that may suggest increased platelet activity. 
      This observation could indicate a potential pathophysiological link between 
      chronic periodontitis and an increased risk of acute coronary syndromes.
FAU - Androsz-Kowalska, Olga
AU  - Androsz-Kowalska O
AD  - Department of Periodontology and Oral Diseases, Medical University of Warsaw, 
      Warsaw, Poland. sluzowki@wum.edu.pl
FAU - Jankowski, Krzysztof
AU  - Jankowski K
FAU - Rymarczyk, Zuzanna
AU  - Rymarczyk Z
FAU - Kowalski, Jan
AU  - Kowalski J
FAU - Pruszczyk, Piotr
AU  - Pruszczyk P
FAU - Gorska, Renata
AU  - Gorska R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Poland
TA  - Kardiol Pol
JT  - Kardiologia polska
JID - 0376352
SB  - IM
CIN - Kardiol Pol. 2013;71(9):1004. PMID: 24297766
CIN - Kardiol Pol. 2013;71(9):1005. PMID: 24479161
MH  - Aged
MH  - Blood Platelets/*metabolism
MH  - Blood Volume
MH  - Chronic Periodontitis/*blood/*complications/diagnosis
MH  - Coronary Artery Disease/*blood/*etiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
EDAT- 2013/06/26 06:00
MHDA- 2013/11/02 06:00
CRDT- 2013/06/26 06:00
PHST- 2013/06/18 00:00 [received]
PHST- 2013/06/18 00:00 [accepted]
PHST- 2013/06/26 06:00 [entrez]
PHST- 2013/06/26 06:00 [pubmed]
PHST- 2013/11/02 06:00 [medline]
AID - VM/OJS/KP/7980 [pii]
AID - 10.5603/KP.2013.0124 [doi]
PST - ppublish
SO  - Kardiol Pol. 2013;71(6):600-5. doi: 10.5603/KP.2013.0124.