PMID- 23798966
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130627
LR  - 20211021
IS  - 1738-3684 (Print)
IS  - 1976-3026 (Electronic)
IS  - 1738-3684 (Linking)
VI  - 10
IP  - 2
DP  - 2013 Jun
TI  - Impact of the BDNF Val66Met Polymorphism on Regional Brain Gray Matter Volumes: 
      Relevance to the Stress Response.
PG  - 173-9
LID - 10.4306/pi.2013.10.2.173 [doi]
AB  - OBJECTIVE: Genetic imaging is used to investigate the mechanism by which genetic 
      variants influence brain structure. In a previous study, a structural change of 
      the dorsolateral prefrontal cortex was associated with symptom modulation in 
      post-traumatic stress disorder patients. This study examined the effect of a 
      polymorphism in the gene encoding brain-derived neurotrophic factor (BDNF) on 
      regional gray matter (GM) volumes and the correlations between the dorsolateral 
      prefrontal GM volume and the stress level in healthy volunteers. METHODS: 
      Sixty-one volunteers underwent genotyping for the BDNF Val66Met single nucleotide 
      polymorphism (SNP) and completed the Stress Response Inventory (SRI). Magnetic 
      resonance images were also acquired, and the effect of each subject's BDNF 
      genotype and SRI subscore on his or her dorsolateral prefrontal GM volume was 
      evaluated. RESULTS: The Val/Val homozygotes had significantly larger GM volumes 
      in the prefrontal cortex and the precuneus, the uncus, and the superior temporal 
      and occipital cortices than Met carriers. The Met homozygotes demonstrated a 
      higher stress response in depression domain than Val/Val and Val/Met groups. A 
      negative correlation between the middle frontal cortex GM volume and the SRI 
      depression subscore was found. CONCLUSION: These findings indicate an interaction 
      between genes and brain structure, and they suggest that differences in 
      dorsolateral prefrontal GM volume related to the BDNF Val66Met SNP are associated 
      with resilience to stressful life events, particularly in the dimension of 
      emotion.
FAU - Kim, Sung Nyun
AU  - Kim SN
AD  - Department of Psychiatry, Seoul National University College of Medicine, Seoul, 
      Republic of Korea. ; Institute of Human Behavioral Medicine, SNU-MRC, Seoul, 
      Republic of Korea.
FAU - Kang, Do-Hyung
AU  - Kang DH
FAU - Yun, Je-Yeon
AU  - Yun JY
FAU - Lee, Tae Young
AU  - Lee TY
FAU - Jung, Wi Hoon
AU  - Jung WH
FAU - Jang, Joon Hwan
AU  - Jang JH
FAU - Kwon, Jun Soo
AU  - Kwon JS
LA  - eng
PT  - Journal Article
DEP - 20130530
PL  - Korea (South)
TA  - Psychiatry Investig
JT  - Psychiatry investigation
JID - 101242994
PMC - PMC3687052
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Dorsolateral prefrontal cortex
OT  - Genetic polymorphism
OT  - Magnetic resonance imaging
OT  - Stress
OT  - Val66Met
EDAT- 2013/06/27 06:00
MHDA- 2013/06/27 06:01
PMCR- 2013/06/01
CRDT- 2013/06/27 06:00
PHST- 2013/01/30 00:00 [received]
PHST- 2013/02/13 00:00 [revised]
PHST- 2013/02/13 00:00 [accepted]
PHST- 2013/06/27 06:00 [entrez]
PHST- 2013/06/27 06:00 [pubmed]
PHST- 2013/06/27 06:01 [medline]
PHST- 2013/06/01 00:00 [pmc-release]
AID - 10.4306/pi.2013.10.2.173 [doi]
PST - ppublish
SO  - Psychiatry Investig. 2013 Jun;10(2):173-9. doi: 10.4306/pi.2013.10.2.173. Epub 
      2013 May 30.