PMID- 23799058
OWN - NLM
STAT- MEDLINE
DCOM- 20140130
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 6
DP  - 2013
TI  - Neural activations during visual sequence learning leave a trace in post-training 
      spontaneous EEG.
PG  - e65882
LID - 10.1371/journal.pone.0065882 [doi]
LID - e65882
AB  - Recent EEG studies have shown that implicit learning involving specific cortical 
      circuits results in an enduring local trace manifested as local changes in 
      spectral power. Here we used a well characterized visual sequence learning task 
      and high density-(hd-)EEG recording to determine whether also declarative 
      learning leaves a post-task, local change in the resting state oscillatory 
      activity in the areas involved in the learning process. Thus, we recorded hd-EEG 
      in normal subjects before, during and after the acquisition of the order of a 
      fixed spatial target sequence (VSEQ) and during the presentation of targets in 
      random order (VRAN). We first determined the temporal evolution of spectral 
      changes during VSEQ and compared it to VRAN. We found significant differences in 
      the alpha and theta bands in three main scalp regions, a right occipito-parietal 
      (ROP), an anterior-frontal (AFr), and a right frontal (RFr) area. The changes in 
      frontal theta power during VSEQ were positively correlated with the learning 
      rate. Further, post-learning EEG recordings during resting state revealed a 
      significant increase in alpha power in ROP relative to a pre-learning baseline. 
      We conclude that declarative learning is associated with alpha and theta changes 
      in frontal and posterior regions that occur during the task, and with an increase 
      of alpha power in the occipito-parietal region after the task. These post-task 
      changes may represent a trace of learning and a hallmark of use-dependent 
      plasticity.
FAU - Moisello, Clara
AU  - Moisello C
AD  - Department of Physiology, Pharmacology and Neuroscience, City University of New 
      York Medical School, New York, New York, United States of America.
FAU - Meziane, Hadj Boumediene
AU  - Meziane HB
FAU - Kelly, Simon
AU  - Kelly S
FAU - Perfetti, Bernardo
AU  - Perfetti B
FAU - Kvint, Svetlana
AU  - Kvint S
FAU - Voutsinas, Nicholas
AU  - Voutsinas N
FAU - Blanco, Daniella
AU  - Blanco D
FAU - Quartarone, Angelo
AU  - Quartarone A
FAU - Tononi, Giulio
AU  - Tononi G
FAU - Ghilardi, Maria Felice
AU  - Ghilardi MF
LA  - eng
GR  - R01 NS054864/NS/NINDS NIH HHS/United States
GR  - R01 NS055185/NS/NINDS NIH HHS/United States
GR  - NS-054864/NS/NINDS NIH HHS/United States
GR  - NS-055185/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130614
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adult
MH  - Alpha Rhythm
MH  - Electroencephalography
MH  - Female
MH  - Frontal Lobe/*physiology
MH  - Humans
MH  - Male
MH  - Memory, Short-Term/*physiology
MH  - Motor Activity
MH  - Parietal Lobe/*physiology
MH  - Photic Stimulation
MH  - Rest/physiology
MH  - Theta Rhythm
MH  - Young Adult
PMC - PMC3683043
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2013/06/27 06:00
MHDA- 2014/01/31 06:00
PMCR- 2013/06/14
CRDT- 2013/06/27 06:00
PHST- 2013/02/20 00:00 [received]
PHST- 2013/04/29 00:00 [accepted]
PHST- 2013/06/27 06:00 [entrez]
PHST- 2013/06/27 06:00 [pubmed]
PHST- 2014/01/31 06:00 [medline]
PHST- 2013/06/14 00:00 [pmc-release]
AID - PONE-D-13-07804 [pii]
AID - 10.1371/journal.pone.0065882 [doi]
PST - epublish
SO  - PLoS One. 2013 Jun 14;8(6):e65882. doi: 10.1371/journal.pone.0065882. Print 2013.