PMID- 23799303
OWN - NLM
STAT- MEDLINE
DCOM- 20131108
LR  - 20191210
IS  - 1520-6025 (Electronic)
IS  - 0163-3864 (Linking)
VI  - 76
IP  - 7
DP  - 2013 Jul 26
TI  - Gombamide A, a cyclic thiopeptide from the sponge Clathria gombawuiensis.
PG  - 1380-3
LID - 10.1021/np4003367 [doi]
AB  - A new peptide, gombamide A (1), was isolated from the marine sponge Clathria 
      gombawuiensis, collected from Korean waters. On the basis of the results of 
      combined spectroscopic analyses, the structure of this compound was determined to 
      be a cyclic C-terminally modified thiohexapeptide containing the unusual amino 
      acid residues para-hydroxystyrylamide (pHSA) and pyroglutamic acid (pyroGlu). The 
      absolute configurations of all amino acid residues were determined to be l by 
      advanced Marfey's analysis. The new compound exhibited weak cytotoxicity against 
      A549 and K562 cell lines as well as moderate inhibitory activity against 
      Na(+)/K(+)-ATPase.
FAU - Woo, Jung-Kyun
AU  - Woo JK
AD  - Natural Products Research Institute, College of Pharmacy, Seoul National 
      University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.
FAU - Jeon, Ju-eun
AU  - Jeon JE
FAU - Kim, Chang-Kwon
AU  - Kim CK
FAU - Sim, Chung J
AU  - Sim CJ
FAU - Oh, Dong-Chan
AU  - Oh DC
FAU - Oh, Ki-Bong
AU  - Oh KB
FAU - Shin, Jongheon
AU  - Shin J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130625
PL  - United States
TA  - J Nat Prod
JT  - Journal of natural products
JID - 7906882
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Peptides, Cyclic)
RN  - 0 (gombamide A)
RN  - EC 7.2.2.13 (Sodium-Potassium-Exchanging ATPase)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/chemistry/*isolation & purification/pharmacology
MH  - Drug Screening Assays, Antitumor
MH  - Humans
MH  - Marine Biology
MH  - Molecular Structure
MH  - Nuclear Magnetic Resonance, Biomolecular
MH  - Peptides, Cyclic/chemistry/*isolation & purification/pharmacology
MH  - Porifera/*chemistry
MH  - Republic of Korea
MH  - Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors
EDAT- 2013/06/27 06:00
MHDA- 2013/11/10 06:00
CRDT- 2013/06/27 06:00
PHST- 2013/06/27 06:00 [entrez]
PHST- 2013/06/27 06:00 [pubmed]
PHST- 2013/11/10 06:00 [medline]
AID - 10.1021/np4003367 [doi]
PST - ppublish
SO  - J Nat Prod. 2013 Jul 26;76(7):1380-3. doi: 10.1021/np4003367. Epub 2013 Jun 25.