PMID- 23799589
OWN - NLM
STAT- MEDLINE
DCOM- 20140213
LR  - 20171116
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Linking)
VI  - 8
IP  - 2
DP  - 2013 Aug
TI  - Expansion of decidual CD45RO(+) T cells with high expression of CEACAM1 in the 
      early stage of pregnancy.
PG  - 571-8
LID - 10.3892/mmr.2013.1552 [doi]
AB  - The aim of the present study was to investigate the mechanism involved in the 
      expansion of CD45RO+ T cells in the decidual microenvironment, and in the 
      expression of the inhibitory carcinoembryonic antigen-related cell adhesion 
      molecule 1 (CEACAM1) on the surface of decidual CD45RO+ T cells. Twenty-one 
      healthy nonpregnant females and seventeen healthy pregnant females in the first 
      trimester were included in the study. Peripheral blood samples from nonpregnant 
      and pregnant females, and decidual tissues from pregnant females following 
      elective abortion, were obtained and analyzed by flow cytometry. The percentages 
      of CD45RO+ T cells and CEACAM1-expressing CD45RO+ T cells were significantly 
      higher in first trimester human decidua than in the peripheral blood. Conditioned 
      medium from the coculture of monocytes and the human trophoblast HTR8/SVneo cell 
      line (MHM) was added to the model for the generation of CD45RO+ T cells in vitro. 
      MHM caused an increase in the percentage of CD45RO+ T cells in a monocyte 
      chemoattractant protein-1 (MCP-1)‑dependent manner and an increase in the 
      percentage of CEACAM1-expressing CD4+CD45RO+ T cells in the model. In conclusion, 
      our results implied that trophoblast cells and monocytes may be involved in the 
      increase of decidual CD45RO+ T cells and the high expression of CEACAM1 on their 
      surfaces.
FAU - Xie, Qi
AU  - Xie Q
AD  - Institute of Basic Medical Sciences, Qilu Hospital, Shandong University, Jinan, 
      Shandong 250012, P.R. China.
FAU - Wang, Qing-Jie
AU  - Wang QJ
FAU - Zhang, Yun
AU  - Zhang Y
FAU - Kong, Bei-Hua
AU  - Kong BH
FAU - Dong, Bai-Hua
AU  - Dong BH
FAU - Qu, Xun
AU  - Qu X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130625
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
RN  - 0 (Antigens, CD)
RN  - 0 (CD66 antigens)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Chemokine CCL2)
RN  - EC 3.1.3.48 (Leukocyte Common Antigens)
SB  - IM
MH  - Adult
MH  - Antigens, CD/genetics/*metabolism
MH  - Cell Adhesion Molecules/genetics/*metabolism
MH  - Cell Line
MH  - Cellular Microenvironment/immunology
MH  - Chemokine CCL2/metabolism
MH  - Decidua/immunology/metabolism
MH  - Female
MH  - Humans
MH  - Leukocyte Common Antigens/*metabolism
MH  - Luteal Phase/immunology/metabolism
MH  - Lymphocyte Activation
MH  - Monocytes/metabolism
MH  - Pregnancy
MH  - Pregnancy Trimester, First
MH  - T-Lymphocyte Subsets/*immunology/*metabolism
MH  - Trophoblasts/metabolism
EDAT- 2013/06/27 06:00
MHDA- 2014/02/14 06:00
CRDT- 2013/06/27 06:00
PHST- 2013/02/05 00:00 [received]
PHST- 2013/06/11 00:00 [accepted]
PHST- 2013/06/27 06:00 [entrez]
PHST- 2013/06/27 06:00 [pubmed]
PHST- 2014/02/14 06:00 [medline]
AID - 10.3892/mmr.2013.1552 [doi]
PST - ppublish
SO  - Mol Med Rep. 2013 Aug;8(2):571-8. doi: 10.3892/mmr.2013.1552. Epub 2013 Jun 25.