PMID- 23799879
OWN - NLM
STAT- MEDLINE
DCOM- 20131126
LR  - 20211021
IS  - 1475-2840 (Electronic)
IS  - 1475-2840 (Linking)
VI  - 12
DP  - 2013 Jun 22
TI  - Association of subclinical myocardial injury with arterial stiffness in patients 
      with type 2 diabetes mellitus.
PG  - 94
LID - 10.1186/1475-2840-12-94 [doi]
AB  - OBJECTIVE: Type 2 diabetes mellitus (T2DM) is associated with subclinical 
      myocardial injury although the underlying mechanism is uncertain. We postulated 
      that arterial stiffness, endothelial dysfunction and subclinical atherosclerosis 
      may contribute to subclinical myocardial injury in patients with T2DM. METHODS: 
      Serum high-sensitivity troponin I (hs-TNI) an indicator of myocardial injury, was 
      measured in 100 patients with T2DM without clinical evidence of macrovascular 
      disease and 150 age and gender-matched controls. Elevated hs-TnI was defined as 
      follow (derived from the 99th percentile from controls): Male >11.1 ng/L; female 
      >7.6 ng/L. Measures that may contribute to myocardial damage in patients with 
      T2DM, including brachial-ankle pulse wave velocity (ba-PWV), brachial flow 
      mediated dilatation (FMD) and carotid intima media thickness (IMT), were also 
      assessed. RESULTS: The serum level of hs-TNI (5.7 +/- 9.2 mug/L vs. 3.2 +/- 1.9 mug/L, 
      P< 0.01) and the prevalence of elevated hs-TNI (12% vs. 4%, P = 0.02) were 
      significantly higher in patients with T2DM than controls. Patients with T2DM also 
      had significantly worse ba-PWV (17.98 +/- 3.91ms-1 vs. 15.70 +/- 2.96 ms-1), brachial 
      FMD (2.6 +/- 3.5% vs. 5.5 +/- 4.2%, P< 0.01) and carotid IMT (0.96 +/- 0.20 mm vs. 0.86 
      +/- 0.14 mm, P< 0.01). In patients with T2DM, hs-TNI was positively correlated with 
      systolic blood pressure (r = 0.31, P<0.01), serum creatinine (r = 0.26, P = 0.01) 
      and ba-PWV (r = 0.34, P< 0.01). Importantly, multiple regression revealed that 
      only ba-PWV was independently associated with hs-TNI (beta = 0.25, P = 0.04). 
      CONCLUSION: The results demonstrated an independent association between ba-PWV 
      and hs-TNI in patients with T2DM with no clinical evidence of macrovascular 
      disease. These findings suggest that increased arterial stiffness is closely 
      related to subclinical myocardial injury in patients with T2DM.
FAU - Yiu, Kai-Hang
AU  - Yiu KH
AD  - Division of Cardiology, Department of Medicine, the University of Hong Kong, Rm 
      1929b, Block K, Queen Mary Hospital, China.
FAU - Zhao, Chun-Ting
AU  - Zhao CT
FAU - Chen, Yan
AU  - Chen Y
FAU - Siu, Chung-Wah
AU  - Siu CW
FAU - Chan, Yap-Hang
AU  - Chan YH
FAU - Lau, Kui-Kai
AU  - Lau KK
FAU - Liu, Shasha
AU  - Liu S
FAU - Lau, Chu-Pak
AU  - Lau CP
FAU - Tse, Hung-Fat
AU  - Tse HF
LA  - eng
PT  - Journal Article
DEP - 20130622
PL  - England
TA  - Cardiovasc Diabetol
JT  - Cardiovascular diabetology
JID - 101147637
RN  - 0 (Troponin I)
SB  - IM
MH  - Aged
MH  - Cardiomyopathies/*blood/complications
MH  - Cardiovascular Diseases/complications
MH  - Carotid Arteries/diagnostic imaging
MH  - Carotid Intima-Media Thickness
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pulse Wave Analysis
MH  - Troponin I/*blood
MH  - *Vascular Stiffness
MH  - Vasodilation
PMC - PMC3706358
EDAT- 2013/06/27 06:00
MHDA- 2013/12/16 06:00
PMCR- 2013/06/22
CRDT- 2013/06/27 06:00
PHST- 2013/03/06 00:00 [received]
PHST- 2013/05/23 00:00 [accepted]
PHST- 2013/06/27 06:00 [entrez]
PHST- 2013/06/27 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
PHST- 2013/06/22 00:00 [pmc-release]
AID - 1475-2840-12-94 [pii]
AID - 10.1186/1475-2840-12-94 [doi]
PST - epublish
SO  - Cardiovasc Diabetol. 2013 Jun 22;12:94. doi: 10.1186/1475-2840-12-94.