PMID- 23800464
OWN - NLM
STAT- MEDLINE
DCOM- 20140422
LR  - 20130910
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 46
DP  - 2013 Oct 1
TI  - Is there a cerebellar compensatory effort in first-episode, treatment-naive major 
      depressive disorder at rest?
PG  - 13-8
LID - S0278-5846(13)00120-6 [pii]
LID - 10.1016/j.pnpbp.2013.06.009 [doi]
AB  - BACKGROUND: This study was undertaken to explore whether there is a cerebellar 
      compensatory response in patients with first-episode, treatment-naive major 
      depressive disorder (MDD). The cerebellar compensatory response is defined as a 
      cerebellar hyperactivity which would be inversely correlated with both the 
      activation of the functionally connected cerebral regions and the depression 
      severity. METHODS: Resting-state functional magnetic resonance imaging (fMRI) 
      data of 24 patients with MDD and 24 healthy subjects were analyzed with the 
      fractional amplitude of low-frequency fluctuations (fALFF) and functional 
      connectivity (FC) methods. The structural images were processed with the 
      voxel-based morphometry (VBM) method. RESULTS: Compared to healthy controls, 
      depressed patients had significantly increased fALFF in the left Crus I and the 
      left cerebellar lobule VI. FC analysis of these two seeded regions found that 
      depressed patients had increased FC between the left Crus I and the right 
      hippocampus, but had decreased FC between the left Crus I and the left inferior 
      parietal lobule (IPL), and between the left cerebellar lobule VI and bilateral 
      inferior temporal gyrus. No correlation was observed between the abnormal fALFF 
      of the seeds and their connected regions and the depression severity or the 
      executive function. The VBM results did not show significant reduction in gray or 
      white matter volume in any above-mentioned region. CONCLUSIONS: Our findings 
      suggest that increased cerebellar activity at resting state may be a disease 
      state phenomenon but not a compensatory response to the dysfunction of the 
      default mode network (DMN) in MDD.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Guo, Wenbin
AU  - Guo W
AD  - Mental Health Center, the First Affiliated Hospital, Guangxi Medical University; 
      Nanning, Guangxi 530021, China. Electronic address: guowenbin76@163.com.
FAU - Liu, Feng
AU  - Liu F
FAU - Liu, Jianrong
AU  - Liu J
FAU - Yu, Liuyu
AU  - Yu L
FAU - Zhang, Zhikun
AU  - Zhang Z
FAU - Zhang, Jian
AU  - Zhang J
FAU - Chen, Huafu
AU  - Chen H
FAU - Xiao, Changqing
AU  - Xiao C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130623
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cerebellum/*metabolism/pathology
MH  - Depressive Disorder, Major/*diagnosis/*metabolism
MH  - Executive Function/*physiology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Rest/*physiology
MH  - Young Adult
OTO - NOTNLM
OT  - AAL
OT  - Anatomical Automatic Labeling
OT  - BOLD
OT  - CSF
OT  - Cerebellum
OT  - DMN
OT  - DPARSF
OT  - Data Processing Assistant for Resting-State fMRI
OT  - Default mode network
OT  - EPI
OT  - FC
OT  - FD
OT  - FOV
OT  - FWHM
OT  - Fractional amplitude of low-frequency fluctuations
OT  - Functional connectivity
OT  - GM
OT  - GRF
OT  - GSReg
OT  - Gaussian Random Field
OT  - HRSD
OT  - Hamilton Rating Scale for Depression
OT  - IPL
OT  - MDD
OT  - MPFC
OT  - MPRAGE
OT  - Major depressive disorder
OT  - PCC/PCu
OT  - ROI
OT  - TI
OT  - TR/TE
OT  - VBM
OT  - VMHC
OT  - WCST
OT  - WM
OT  - Wisconsin Card Sorting Test
OT  - blood oxygen level-dependent
OT  - cerebrospinal fluid
OT  - default mode network
OT  - echo-planar imaging
OT  - fALFF
OT  - fMRI
OT  - field of view
OT  - fractional amplitude of low-frequency fluctuations
OT  - framewise displacement
OT  - full width at half maximum
OT  - functional connectivity
OT  - functional magnetic resonance imaging
OT  - global signal regression
OT  - gray matter
OT  - inferior parietal lobule
OT  - inversion time
OT  - magnetization-prepared rapid gradient echo
OT  - major depressive disorder
OT  - medial prefrontal cortex
OT  - posterior cingulate cortex/precuneus
OT  - region of interest
OT  - repetition time/echo time
OT  - voxel-based morphometry
OT  - voxel-mirrored homotopic connectivity
OT  - white matter
EDAT- 2013/06/27 06:00
MHDA- 2014/04/23 06:00
CRDT- 2013/06/27 06:00
PHST- 2013/05/05 00:00 [received]
PHST- 2013/06/04 00:00 [revised]
PHST- 2013/06/13 00:00 [accepted]
PHST- 2013/06/27 06:00 [entrez]
PHST- 2013/06/27 06:00 [pubmed]
PHST- 2014/04/23 06:00 [medline]
AID - S0278-5846(13)00120-6 [pii]
AID - 10.1016/j.pnpbp.2013.06.009 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2013 Oct 1;46:13-8. doi: 
      10.1016/j.pnpbp.2013.06.009. Epub 2013 Jun 23.