PMID- 23801989
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130627
LR  - 20211021
IS  - 1664-3224 (Print)
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 4
DP  - 2013
TI  - Dendritic cells in the periphery control antigen-specific natural and induced 
      regulatory T cells.
PG  - 151
LID - 10.3389/fimmu.2013.00151 [doi]
LID - 151
AB  - Dendritic cells (DCs) are specialized antigen-presenting cells that regulate both 
      immunity and tolerance. DCs in the periphery play a key role in expanding 
      naturally occurring Foxp3(+) CD25(+) CD4(+) regulatory T cells (Natural T-regs) 
      and inducing Foxp3 expression (Induced T-regs) in Foxp3(-) CD4(+) T cells. DCs 
      are phenotypically and functionally heterogeneous, and further classified into 
      several subsets depending on distinct marker expression and their location. 
      Recent findings indicate the presence of specialized DC subsets that act to 
      expand Natural T-regs or induce Foxp3(+) T-regs from Foxp3(-) CD4(+) T cells. For 
      example, two major subsets of DCs in lymphoid organs act differentially in 
      inducing Foxp3(+) T-regs from Foxp3(-) cells or expanding Natural T-regs with 
      model-antigen delivery by anti-DC subset monoclonal antibodies in vivo. 
      Furthermore, DCs expressing CD103 in the intestine induce Foxp3(+) T-regs from 
      Foxp3(-) CD4(+) T cells with endogenous TGF-beta and retinoic acid. In addition, 
      antigen-presenting DCs have a capacity to generate Foxp3(+) T-regs in the oral 
      cavity where many antigens and commensals exist, similar to intestine and skin. 
      In skin and skin-draining lymph nodes, at least six DC subsets have been 
      identified, suggesting a complex DC-T-reg network. Here, we will review the 
      specific activity of DCs in expanding Natural T-regs and inducing Foxp3(+) T-regs 
      from Foxp3(-) precursors, and further discuss the critical function of DCs in 
      maintaining tolerance at various locations including skin and oral cavity.
FAU - Yamazaki, Sayuri
AU  - Yamazaki S
AD  - Department of Geriatric and Environmental Dermatology, Graduate School of Medical 
      Sciences, Nagoya City University , Nagoya , Japan.
FAU - Morita, Akimichi
AU  - Morita A
LA  - eng
PT  - Journal Article
DEP - 20130621
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC3689032
OTO - NOTNLM
OT  - Foxp3
OT  - antigen
OT  - dendritic cells
OT  - subset
OT  - tolerance
EDAT- 2013/06/27 06:00
MHDA- 2013/06/27 06:01
PMCR- 2013/01/01
CRDT- 2013/06/27 06:00
PHST- 2013/04/30 00:00 [received]
PHST- 2013/06/04 00:00 [accepted]
PHST- 2013/06/27 06:00 [entrez]
PHST- 2013/06/27 06:00 [pubmed]
PHST- 2013/06/27 06:01 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2013.00151 [doi]
PST - epublish
SO  - Front Immunol. 2013 Jun 21;4:151. doi: 10.3389/fimmu.2013.00151. eCollection 
      2013.