PMID- 23803115
OWN - NLM
STAT- MEDLINE
DCOM- 20141014
LR  - 20190606
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 14
IP  - 5
DP  - 2013
TI  - Tumor necrosis factor-alpha 238 G/A polymorphism and risk of hepatocellular 
      carcinoma: evidence from a meta-analysis.
PG  - 3275-9
AB  - BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) plays a very important role in the 
      development and progression of cancer. Many epidemiological studies have 
      evaluated associations between the TNF-alpha 238 G/A polymorphism and hepatocellular 
      carcinoma (HCC) risk, but the published data are inconclusive. Therefore, we 
      performed the present meta-analysis. METHODS: Electronic searches of several 
      databases were conducted for all publications on the association between TNF-alpha 
      238 G/A polymorphism and HCC through July 2012. Asummary odds ratio (OR) with its 
      95% confidence interval (CI) were calculated to evaluate the strength of this 
      association. RESULTS: Eleven case-control studies with a total of 1,572 HCC cases 
      and 1,875 controls were finally included in this meta-analysis. Overall, the 
      TNF-alpha 238 G/A polymorphism was significantly associated with increased risk of 
      hepatocellular carcinoma in three genetic comparison models (For A versus G: OR 
      1.32, 95%CI 1.04-1.69, P = 0.02, I2 = 40%; for AG versus GG: OR 1.32, 95%CI 
      1.02-1.71, P = 0.03, I2 = 40%; for AA/AG versus GG: OR 1.33, 95%CI 1.03-1.72, P = 
      0.03, I2 = 41%) when all studies were pooled. Subgroup analysis by ethnicity 
      further showed that there was a significant association between the TNF-alpha 238 G/A 
      polymorphism and risk of HCC in Asians under three genetic comparison models (For 
      A versus G: OR 1.30, 95%CI 1.00-1.68, P = 0.05, I2 = 45% for AA/AG versus GG: OR 
      1.31, 95%CI 1.00-1.71, P = 0.05, I2 = 46%). CONCLUSIONS: This meta-analysis 
      provided convincing evidence that the TNF-alpha 238 G/A polymorphism is associated 
      with increased susceptibility to HCC. However, more well-designed studies with 
      large sample size are needed to validate this association in Caucasians.
FAU - Cheng, Ke
AU  - Cheng K
AD  - 35 Ward of Transplantation, The Third Xiangya hospital of Central South 
      University, Changsha, China.
FAU - Zhao, Yu-Jun
AU  - Zhao YJ
FAU - Liu, Lian
AU  - Liu L
FAU - Wan, Jing-Jing
AU  - Wan JJ
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Carcinoma, Hepatocellular/*genetics
MH  - Case-Control Studies
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Liver Neoplasms/*genetics
MH  - Polymorphism, Genetic/*genetics
MH  - Prognosis
MH  - Risk Factors
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2013/06/28 06:00
MHDA- 2014/10/15 06:00
CRDT- 2013/06/28 06:00
PHST- 2013/06/28 06:00 [entrez]
PHST- 2013/06/28 06:00 [pubmed]
PHST- 2014/10/15 06:00 [medline]
AID - 10.7314/apjcp.2013.14.5.3275 [doi]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2013;14(5):3275-9. doi: 10.7314/apjcp.2013.14.5.3275.