PMID- 23803259
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20240117
IS  - 1532-429X (Electronic)
IS  - 1097-6647 (Print)
IS  - 1097-6647 (Linking)
VI  - 15
IP  - 1
DP  - 2013 Jun 26
TI  - Multi-contrast late enhancement CMR determined gray zone and papillary muscle 
      involvement predict appropriate ICD therapy in patients with ischemic heart 
      disease.
PG  - 57
LID - 10.1186/1532-429X-15-57 [doi]
AB  - BACKGROUND: Myocardial infarct heterogeneity indices including peri-infarct gray 
      zone are predictors for spontaneous ventricular arrhythmias events after ICD 
      implantation in patients with ischemic heart disease. In this study we 
      hypothesize that the extent of peri-infarct gray zone and papillary muscle 
      infarct scores determined by a new multi-contrast late enhancement (MCLE) method 
      may predict appropriate ICD therapy in patients with ischemic heart disease. 
      METHODS: The cardiovascular magnetic resonance (CMR) protocol included LV 
      functional parameter assessment and late gadolinium enhancement (LGE) CMR using 
      the conventional method and MCLE post-contrast. The proportion of peri-infarct 
      gray zone, core infarct, total infarct relative to LV myocardium mass, papillary 
      muscle infarct scores, and LV functional parameters were statistically compared 
      between groups with and without appropriate ICD therapy during follow-up. 
      RESULTS: Twenty-five patients with prior myocardial infarct for planned ICD 
      implantation (age 64+/-10 yrs, 88% men, average LVEF 26.2+/-10.4%) were enrolled. All 
      patients completed the CMR protocol and 6-46 months follow-up at the ICD clinic. 
      Twelve patients had at least one appropriate ICD therapy for ventricular 
      arrhythmias at follow-up. Only the proportion of gray zone measured with MCLE and 
      papillary muscle infarct scores demonstrated a statistically significant 
      difference (P < 0.05) between patients with and without appropriate ICD therapy 
      for ventricular arrhythmias; other CMR derived parameters such as LVEF, core 
      infarct and total infarct did not show a statistically significant difference 
      between these two groups. CONCLUSIONS: Peri-infarct gray zone measurement using 
      MCLE, compared to using conventional LGE-CMR, might be more sensitive in 
      predicting appropriate ICD therapy for ventricular arrhythmia events. Papillary 
      muscle infarct scores might have a specific role for predicting appropriate ICD 
      therapy although the exact mechanism needs further investigation.
FAU - Yang, Yuesong
AU  - Yang Y
FAU - Connelly, Kim A
AU  - Connelly KA
FAU - Zeidan-Shwiri, Tawfiq
AU  - Zeidan-Shwiri T
FAU - Lu, Yingli
AU  - Lu Y
FAU - Paul, Gideon
AU  - Paul G
FAU - Roifman, Idan
AU  - Roifman I
FAU - Zia, Mohammad I
AU  - Zia MI
FAU - Graham, John J
AU  - Graham JJ
FAU - Dick, Alexander J
AU  - Dick AJ
FAU - Crystal, Eugene
AU  - Crystal E
FAU - Wright, Graham A
AU  - Wright GA
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130626
PL  - England
TA  - J Cardiovasc Magn Reson
JT  - Journal of cardiovascular magnetic resonance : official journal of the Society 
      for Cardiovascular Magnetic Resonance
JID - 9815616
RN  - 0 (Contrast Media)
SB  - IM
MH  - Aged
MH  - Arrhythmias, Cardiac/diagnosis/etiology/physiopathology/*therapy
MH  - *Contrast Media
MH  - *Defibrillators, Implantable
MH  - Electric Countershock/*instrumentation
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/complications/*diagnosis/pathology/physiopathology
MH  - Papillary Muscles/*pathology/physiopathology
MH  - *Patient Selection
MH  - Predictive Value of Tests
MH  - Stroke Volume
MH  - Ventricular Function, Left
PMC - PMC3702486
EDAT- 2013/06/28 06:00
MHDA- 2015/03/31 06:00
PMCR- 2013/06/26
CRDT- 2013/06/28 06:00
PHST- 2013/02/01 00:00 [received]
PHST- 2013/06/13 00:00 [accepted]
PHST- 2013/06/28 06:00 [entrez]
PHST- 2013/06/28 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
PHST- 2013/06/26 00:00 [pmc-release]
AID - S1097-6647(23)00773-1 [pii]
AID - 1532-429X-15-57 [pii]
AID - 10.1186/1532-429X-15-57 [doi]
PST - epublish
SO  - J Cardiovasc Magn Reson. 2013 Jun 26;15(1):57. doi: 10.1186/1532-429X-15-57.