PMID- 23804111
OWN - NLM
STAT- MEDLINE
DCOM- 20130905
LR  - 20211021
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 33
IP  - 26
DP  - 2013 Jun 26
TI  - Distinct familiarity-based response patterns for faces and buildings in 
      perirhinal and parahippocampal cortex.
PG  - 10915-23
LID - 10.1523/JNEUROSCI.0126-13.2013 [doi]
AB  - An unresolved question in our understanding of the medial temporal lobes is how 
      functional differences between structures pertaining to stimulus category relate 
      to the distinction between item-based and contextually based recognition-memory 
      processes. Specifically, it remains unclear whether perirhinal cortex (PrC) 
      supports item-based familiarity signals for all stimulus categories or whether 
      parahippocampal cortex (PhC) may also play a role for stimulus categories that 
      are known to engage this structure in other task contexts. Here, we used 
      multivoxel pattern analyses of fMRI data to compare patterns of activity in 
      humans that are associated with the perceived familiarity of faces, buildings, 
      and chairs. During scanning, participants judged the familiarity of previously 
      studied and novel items from all three categories. Instances in which recognition 
      was based on recollection were removed from all analyses. In right PrC, we found 
      patterns of activity that distinguished familiar from novel faces. By contrast, 
      in right PhC, we observed such patterns for buildings. Familiarity signals for 
      chairs were present in both structures but shared little overlap with the 
      patterns observed for faces and buildings on a more fine-grained scale. In the 
      hippocampus, we found no evidence for familiarity signals for any object 
      category. Our findings show that both PrC and PhC contribute to the assessment of 
      item familiarity. They suggest that PhC does not only represent episodic context 
      but can also represent item information for some object categories in 
      recognition-memory decisions. In turn, our findings also indicate that the 
      involvement of PrC in representing item familiarity is not ubiquitous.
FAU - Martin, Chris B
AU  - Martin CB
AD  - The Brain and Mind Institute and Department of Psychology, University of Western 
      Ontario, London, Ontario, Canada N6A 5B7.
FAU - McLean, David A
AU  - McLean DA
FAU - O'Neil, Edward B
AU  - O'Neil EB
FAU - Kohler, Stefan
AU  - Kohler S
LA  - eng
GR  - MOP93644/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
SB  - IM
MH  - Adult
MH  - *Face
MH  - Female
MH  - Hippocampus/*physiology
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Judgment/physiology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Memory/physiology
MH  - Parahippocampal Gyrus/*physiology
MH  - Photic Stimulation
MH  - Psychomotor Performance/physiology
MH  - Recognition, Psychology/*physiology
MH  - Visual Perception/*physiology
MH  - Young Adult
PMC - PMC6618503
EDAT- 2013/06/28 06:00
MHDA- 2013/09/06 06:00
PMCR- 2013/12/26
CRDT- 2013/06/28 06:00
PHST- 2013/06/28 06:00 [entrez]
PHST- 2013/06/28 06:00 [pubmed]
PHST- 2013/09/06 06:00 [medline]
PHST- 2013/12/26 00:00 [pmc-release]
AID - 33/26/10915 [pii]
AID - 0126-13 [pii]
AID - 10.1523/JNEUROSCI.0126-13.2013 [doi]
PST - ppublish
SO  - J Neurosci. 2013 Jun 26;33(26):10915-23. doi: 10.1523/JNEUROSCI.0126-13.2013.