PMID- 23804320
OWN - NLM
STAT- MEDLINE
DCOM- 20131209
LR  - 20171116
IS  - 1097-4652 (Electronic)
IS  - 0021-9541 (Linking)
VI  - 229
IP  - 1
DP  - 2014 Jan
TI  - Activated ERK/FOXM1 pathway by low-power laser irradiation inhibits UVB-induced 
      senescence through down-regulating p21 expression.
PG  - 108-16
LID - 10.1002/jcp.24425 [doi]
AB  - Cellular senescence is a growth-arrest program that limits cell proliferation. 
      Low-power laser irradiation (LPLI) has been demonstrated to promote cell 
      proliferation. However, whether LPLI can inhibit cellular senescence remains 
      unknown. In the present study, to investigate the functional role of LPLI against 
      skin aging, we used ultraviolet radiation b (UVB) to induce cell senescence. We 
      first report that LPLI can delay UVB-induced cell senescence. The 
      senescence-associated beta-galactosidase (SA-beta-Gal) activity and p21 expression, 
      hallmarks of senescent cells, were decreased in the Forkhead box transcription 
      factor FOXM1-dependent manner under treatment with LPLI. The effect of LPLI was 
      further enhanced with an overexpression of FOXM1, and abolished when FOXM1 was 
      knockdown with short hairpin RNA (shRNA). Furthermore, LPLI activated the 
      extracellular regulated protein kinases (ERK) that was upstream of FOXM1. This 
      led to FOXM1 phosphorylation and nuclear translocation. Nuclear translocation 
      enhanced FOXM1 transcriptional activity and promoted its downstream target gene 
      c-Myc expression that could inhibit p21 expression. These findings highlight the 
      protective effects of ERK/FOXM1 pathway against UVB-induced cell senescence, 
      suggesting a potential protecting strategy for treating skin aging by LPLI.
CI  - (c) 2013 Wiley Periodicals, Inc.
FAU - Ling, Qingzhou
AU  - Ling Q
AD  - MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, 
      College of Biophotonics, South China Normal University, Guangzhou, China.
FAU - Meng, Chengbo
AU  - Meng C
FAU - Chen, Qun
AU  - Chen Q
FAU - Xing, Da
AU  - Xing D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Cell Physiol
JT  - Journal of cellular physiology
JID - 0050222
RN  - 0 (Forkhead Box Protein M1)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Foxm1 protein, mouse)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Apoptosis/radiation effects
MH  - Cell Proliferation/radiation effects
MH  - Cellular Senescence/*radiation effects
MH  - Fibroblasts/radiation effects
MH  - Forkhead Box Protein M1
MH  - Forkhead Transcription Factors/*metabolism
MH  - Humans
MH  - *Low-Level Light Therapy
MH  - MAP Kinase Signaling System/radiation effects
MH  - Mice
MH  - NIH 3T3 Cells
MH  - Phosphorylation/radiation effects
MH  - Skin Aging/genetics/*radiation effects
MH  - *Ultraviolet Rays
EDAT- 2013/06/28 06:00
MHDA- 2013/12/16 06:00
CRDT- 2013/06/28 06:00
PHST- 2013/04/15 00:00 [received]
PHST- 2013/06/20 00:00 [accepted]
PHST- 2013/06/28 06:00 [entrez]
PHST- 2013/06/28 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1002/jcp.24425 [doi]
PST - ppublish
SO  - J Cell Physiol. 2014 Jan;229(1):108-16. doi: 10.1002/jcp.24425.