PMID- 23805237
OWN - NLM
STAT- MEDLINE
DCOM- 20171006
LR  - 20220310
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 6
DP  - 2013
TI  - Interleukin-10 -592C/A, -819C/T and -1082A/G Polymorphisms with Risk of Type 2 
      Diabetes Mellitus: A HuGE Review and Meta-analysis.
PG  - e66568
LID - 10.1371/journal.pone.0066568 [doi]
LID - e66568
AB  - BACKGROUND: Several studies have been conducted in recent years to evaluate the 
      risk of type 2 diabetes mellitus (T2DM) and polymorphisms of interleukin (IL)-10. 
      However, the results remain conflicting rather than conclusive. This 
      meta-analysis aimed to summarize the current evidence from case-control studies 
      that evaluated this association. METHODS: We carried out a search in Medline, 
      EMBASE, and the Chinese National Knowledge Infrastructure (CNKI) database for 
      relevant studies. Data were extracted using a standardized form and pooled odds 
      ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the 
      strength of the association. RESULTS: 10 studies were included in our 
      meta-analysis and systemic review. Our meta-analysis indicated that IL-10 
      -1082A/G polymorphism was associated with the risk of T2DM (GA vs. AA: OR = 1.21, 
      95% CI = 1.03-1.14; GA/GG vs. AA: OR = 1.22, 95% CI = 1.05-1.41), whereas there 
      was no association between IL-10 -592C/A (CC/CA vs. AA: OR = 1.07, 95% 
      CI = 0.59-1.93) or -819C/T (CC/CT vs. TT: OR = 0.93, 95% CI = 0.49-1.75) 
      polymorphism and T2DM risk was found in our study. CONCLUSIONS: This 
      meta-analysis provides strong evidence that IL-10 -1082A/G polymorphism 
      associated with risk of T2DM. However, no association of the IL-10 -592C/A or 
      -819C/T polymorphism with T2DM risk was found. Additional well-designed large 
      studies were required for the validation of our results.
FAU - Hua, Yanyin
AU  - Hua Y
AD  - Department of Endocrinology, Zhejiang Provincial People's Hospital, Hangzhou, 
      China.
FAU - Shen, Jie
AU  - Shen J
FAU - Song, Yingxiang
AU  - Song Y
FAU - Xing, Yubo
AU  - Xing Y
FAU - Ye, Xiao
AU  - Ye X
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20130621
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (IL10 protein, human)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Interleukin-10/*genetics
MH  - Male
MH  - *Polymorphism, Genetic
MH  - Risk Factors
PMC - PMC3689758
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2013/06/28 06:00
MHDA- 2013/06/28 06:01
PMCR- 2013/06/21
CRDT- 2013/06/28 06:00
PHST- 2013/03/26 00:00 [received]
PHST- 2013/04/16 00:00 [accepted]
PHST- 2013/06/28 06:00 [entrez]
PHST- 2013/06/28 06:00 [pubmed]
PHST- 2013/06/28 06:01 [medline]
PHST- 2013/06/21 00:00 [pmc-release]
AID - PONE-D-13-12836 [pii]
AID - 10.1371/journal.pone.0066568 [doi]
PST - epublish
SO  - PLoS One. 2013 Jun 21;8(6):e66568. doi: 10.1371/journal.pone.0066568. Print 2013.