PMID- 23805406
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130628
LR  - 20211021
IS  - 2162-3945 (Print)
IS  - 2162-397X (Electronic)
IS  - 2162-3945 (Linking)
VI  - 2
IP  - 2
DP  - 2013 Apr 1
TI  - CCR5: A novel player in the adipose tissue inflammation and insulin resistance?
PG  - 99-103
LID - 10.4161/adip.22420 [doi]
AB  - Adipose tissue macrophage (ATM) accumulation through C-C motif chemokine receptor 
      2 (CCR2) and its ligand monocyte chemoattractant protein-1 (MCP-1) is considered 
      pivotal in the development of insulin resistance. However, our new study has 
      demonstrated that CCR5, a different CC chemokine receptor, plays an important 
      role in the ATM recruitment and activation and subsequent development of insulin 
      resistance (see the recent article in Diabetes). Although recent human studies 
      have shown upregulation of the expression of not only MCP-1-CCR2 but also other 
      CC chemokines and their receptors in the visceral fat of obese individuals, it is 
      not known if CCR5 is involved in ATM recruitment and insulin resistance. This 
      article has shown several new important observations. First, expression of CCR5 
      and its ligands is significantly increased and is equal to that of CCR2 and its 
      ligands in the white adipose tissue (WAT) of obese mice, particularly in the 
      macrophage fraction. Second, fluorescence-activated cell sorter analysis clearly 
      demonstrates a robust increase in accumulation of CCR5(+) ATMs in response to a 
      high fat (HF) diet. Third, and most important, two distinct models, both Ccr5 
      (-/-) mice and chimeric mice lacking CCR5 only in myeloid cells, are protected 
      from insulin resistance and diabetes through reduction in ATM accumulation. 
      Finally, it is interesting that an alternatively activated, M2-dominant shift in 
      ATM is induced in obese Ccr5 (-/-) mice. Taken together, these data indicate that 
      CCR5 is a novel link between obesity, adipose tissue inflammation, and insulin 
      resistance.
FAU - Ota, Tsuguhito
AU  - Ota T
AD  - Department of Cell Metabolism and Nutrition; Brain/Liver Interface Medicine 
      Research Center; Kanazawa University; Kanazawa, Ishikawa Japan.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Adipocyte
JT  - Adipocyte
JID - 101567863
CON - Kitade H, Sawamoto K, Nagashimada M, Inoue H, Yamamoto Y, Sai Y, et al. CCR5 
      plays a critical role in obesity-induced adipose tissue inflammation and insulin 
      resistance by regulating both macrophage recruitment and M1/M2 status. Diabetes. 
      2012;61:1680-90. doi: 10.2337/db11-1506.
PMC - PMC3661115
OTO - NOTNLM
OT  - CCR2
OT  - CCR5
OT  - MCP-1
OT  - TNF-alpha
OT  - adipose tissue macrophage
OT  - chemokine
OT  - chemokine receptor
OT  - inflammation
OT  - insulin resistance
OT  - obesity
EDAT- 2013/06/28 06:00
MHDA- 2013/06/28 06:01
PMCR- 2013/04/01
CRDT- 2013/06/28 06:00
PHST- 2012/07/03 00:00 [received]
PHST- 2012/09/28 00:00 [revised]
PHST- 2012/10/01 00:00 [accepted]
PHST- 2013/06/28 06:00 [entrez]
PHST- 2013/06/28 06:00 [pubmed]
PHST- 2013/06/28 06:01 [medline]
PHST- 2013/04/01 00:00 [pmc-release]
AID - 2012ADIPOCYTE062R [pii]
AID - 10.4161/adip.22420 [doi]
PST - ppublish
SO  - Adipocyte. 2013 Apr 1;2(2):99-103. doi: 10.4161/adip.22420.