PMID- 23805816
OWN - NLM
STAT- MEDLINE
DCOM- 20150109
LR  - 20221207
IS  - 1943-3670 (Electronic)
IS  - 0022-3492 (Linking)
VI  - 85
IP  - 4
DP  - 2014 Apr
TI  - Resistin levels in gingival crevicular fluid of patients with chronic 
      periodontitis and type 2 diabetes mellitus.
PG  - 610-7
LID - 10.1902/jop.2013.130092 [doi]
AB  - BACKGROUND: Resistin is associated with local and systemic inflammatory 
      conditions with a direct correlation with type 2 diabetes mellitus (T2DM). The 
      aim of this clinico-biochemical study is to estimate and compare the levels of 
      resistin in the gingival crevicular fluid (GCF) in health, chronic periodontitis 
      (CP), and T2DM. METHODS: Sixty patients (aged >35 years) who participated in this 
      study were divided into four groups of 15 patients each: healthy individuals 
      (group 1), patients with CP (group 2), patients with T2DM (group 3), and patients 
      with T2DM and CP (group 4). The parameters assessed included plaque index (PI), 
      gingival index (GI), probing depth (PD), periodontal index, body mass index, 
      random blood sugar (RBS), and glycated hemoglobin (HbA1c). GCF (4 muL) was 
      collected and analyzed for resistin levels using an enzyme-linked immunosorbent 
      assay. RESULTS: Resistin was detected in the GCF of all patients. A significant 
      difference was observed in GCF resistin concentrations from group 1 versus group 
      2 (P = 0.0093), group 3 (P = 0.0341), and group 4 (P = 0.0002); in group 2 versus 
      group 4 (P = 0.0032); and in group 3 versus group 4 (P = 0.0008). When all the 
      samples were analyzed together, GCF resistin levels positively correlated with 
      GI, PD, PI, RBS, and HbA1c and were predictable with PD and HbA1c. CONCLUSIONS: 
      Resistin levels are increased in CP and T2DM. Hence, GCF resistin levels may be 
      considered as a potential inflammatory marker for periodontitis with T2DM.
FAU - Gokhale, Neeraja H
AU  - Gokhale NH
AD  - Department of Periodontics, Sri Dharmasthala Manjunatheshwara College of Dental 
      Sciences & Hospital.
FAU - Acharya, Anirudh B
AU  - Acharya AB
FAU - Patil, Vidya S
AU  - Patil VS
FAU - Trivedi, Dheeraj J
AU  - Trivedi DJ
FAU - Setty, Swati
AU  - Setty S
FAU - Thakur, Srinath L
AU  - Thakur SL
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20130627
PL  - United States
TA  - J Periodontol
JT  - Journal of periodontology
JID - 8000345
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Inflammation Mediators)
RN  - 0 (RETN protein, human)
RN  - 0 (Resistin)
SB  - IM
MH  - Adult
MH  - Alveolar Bone Loss/classification/metabolism
MH  - Biomarkers/analysis
MH  - Blood Glucose/analysis
MH  - Body Mass Index
MH  - Chronic Periodontitis/*metabolism
MH  - Dental Plaque Index
MH  - Diabetes Mellitus, Type 2/*metabolism
MH  - Female
MH  - Gingival Crevicular Fluid/*chemistry
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Inflammation Mediators/analysis
MH  - Male
MH  - Middle Aged
MH  - Periodontal Index
MH  - Periodontal Pocket/classification/metabolism
MH  - Periodontium/metabolism
MH  - Resistin/*analysis
EDAT- 2013/06/29 06:00
MHDA- 2015/01/13 06:00
CRDT- 2013/06/29 06:00
PHST- 2013/06/29 06:00 [entrez]
PHST- 2013/06/29 06:00 [pubmed]
PHST- 2015/01/13 06:00 [medline]
AID - 10.1902/jop.2013.130092 [doi]
PST - ppublish
SO  - J Periodontol. 2014 Apr;85(4):610-7. doi: 10.1902/jop.2013.130092. Epub 2013 Jun 
      27.