PMID- 23806197
OWN - NLM
STAT- MEDLINE
DCOM- 20140904
LR  - 20140113
IS  - 1444-2892 (Electronic)
IS  - 1443-9506 (Linking)
VI  - 23
IP  - 1
DP  - 2014 Jan
TI  - Left ventricular volumes and systolic function after long-term right ventricular 
      pacing may be predicted by paced QRS duration, but not pacing site.
PG  - 43-8
LID - S1443-9506(13)00352-1 [pii]
LID - 10.1016/j.hlc.2013.04.122 [doi]
AB  - BACKGROUND: Long-term right ventricular apical (RVA) pacing causes adverse left 
      ventricular (LV) remodelling and clinical outcomes. METHODS: Forty-one patients 
      (19 men, mean age 70.9+/-14.2, 23 right ventricular septal and 18 RVA pacing) 
      underwent pacemaker implantation for atrioventricular block. LV volumes and left 
      ventricular ejection fraction (LVEF) were assessed by echocardiography 39.3+/-17.2 
      months after implantation. Predictors of left ventricular systolic volume 
      (LVESV), left ventricular diastolic volume (LVEDV) and LVEF were analysed. 
      RESULTS: No difference was found between RVA pacing and right ventricular septal 
      pacing groups in LVESV (40.6+/-22.6 vs 33+/-14.4ml; p=0.199), LVEDV (88.2+/-31.2 vs 
      73.7+/-23.9ml; p=0.102) and LVEF (56.1+/-8.6 vs 56+/-6.6%; p=0.996). With multivariate 
      stepwise regression, only pQRSd and renal impairment independently predicted 
      LVESV (beta=0.522, 95% CI: 0.242-0.802; p=0.001 and beta=40.3, 95% CI: 17.6-62.9; 
      p=0.001 respectively), LVEDV (beta=0.786, 95% CI: 0.338-1.235; p=0.001 and beta=42.8, 
      95% CI: 6.6-79; p=0.022 respectively) and LVEF (beta=-0.161, 95% CI: -0.283 to 
      -0.04; p=0.011 and beta=-14.8, 95% CI: -24.6 to -5.0; p=0.004 respectively). 
      CONCLUSIONS: pQRSd and renal impairment, but not pacing site or baseline LVEF, 
      may be predictors for LV volumes and systolic function after long-term RV pacing. 
      pQRSd may be target for pacing site optimisation.
CI  - Copyright (c) 2013 Australian and New Zealand Society of Cardiac and Thoracic 
      Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). 
      Published by Elsevier B.V. All rights reserved.
FAU - Chan, Ngai-Yin
AU  - Chan NY
AD  - Princess Margaret Hospital, Hong Kong. Electronic address: 
      ngaiyinchan@yahoo.com.hk.
FAU - Yuen, Ho-Chuen
AU  - Yuen HC
AD  - Princess Margaret Hospital, Hong Kong.
FAU - Choy, Chi-Chung
AU  - Choy CC
AD  - Princess Margaret Hospital, Hong Kong.
FAU - Mok, Ngai-Shing
AU  - Mok NS
AD  - Princess Margaret Hospital, Hong Kong.
FAU - Tsui, Ping-Tim
AU  - Tsui PT
AD  - Princess Margaret Hospital, Hong Kong.
FAU - Lau, Chun-Leung
AU  - Lau CL
AD  - Princess Margaret Hospital, Hong Kong.
FAU - Lo, Ying-Keung
AU  - Lo YK
AD  - Princess Margaret Hospital, Hong Kong.
FAU - Chu, Pui-Shan
AU  - Chu PS
AD  - Princess Margaret Hospital, Hong Kong.
FAU - Chow, Hoi-Fan
AU  - Chow HF
AD  - Princess Margaret Hospital, Hong Kong.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20130625
PL  - Australia
TA  - Heart Lung Circ
JT  - Heart, lung & circulation
JID - 100963739
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Cardiac Pacing, Artificial
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Pacemaker, Artificial
MH  - Retrospective Studies
MH  - *Stroke Volume
MH  - *Ventricular Function, Left
MH  - *Ventricular Remodeling
OTO - NOTNLM
OT  - Cardiac pacing
OT  - Electrocardiography
OT  - Left ventricular remodelling
OT  - Left ventricular volumes
OT  - Right ventricular apical pacing
OT  - Right ventricular septal pacing
EDAT- 2013/06/29 06:00
MHDA- 2014/09/05 06:00
CRDT- 2013/06/29 06:00
PHST- 2013/01/28 00:00 [received]
PHST- 2013/04/23 00:00 [revised]
PHST- 2013/04/27 00:00 [accepted]
PHST- 2013/06/29 06:00 [entrez]
PHST- 2013/06/29 06:00 [pubmed]
PHST- 2014/09/05 06:00 [medline]
AID - S1443-9506(13)00352-1 [pii]
AID - 10.1016/j.hlc.2013.04.122 [doi]
PST - ppublish
SO  - Heart Lung Circ. 2014 Jan;23(1):43-8. doi: 10.1016/j.hlc.2013.04.122. Epub 2013 
      Jun 25.