PMID- 23806201
OWN - NLM
STAT- MEDLINE
DCOM- 20131223
LR  - 20220330
IS  - 1879-0372 (Electronic)
IS  - 0952-7915 (Print)
IS  - 0952-7915 (Linking)
VI  - 25
IP  - 4
DP  - 2013 Aug
TI  - Impact of aging on antigen presentation cell function of dendritic cells.
PG  - 535-41
LID - S0952-7915(13)00097-6 [pii]
LID - 10.1016/j.coi.2013.05.016 [doi]
AB  - Older people exhibit increased mortality to infections and cancer as compared to 
      younger people, indicating that aging impairs immunity. Dendritic cells (DCs) are 
      key for bridging the innate and adaptive arms of the immune system by priming 
      antigen specific T cells. Discerning how aging impacts DC function to initiate 
      adaptive immune responses is of great biomedical importance as this could lead to 
      the development of novel therapeutics to enhance immunity with aging. This review 
      details reports indicating that aging impairs the antigen presenting function of 
      DCs but highlights other studies indicating preserved DC function with aging. How 
      aging impacts antigen presentation by DCs is complex and without a clear unifying 
      biological underpinning.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Wong, Christine
AU  - Wong C
AD  - Department of Internal Medicine, Yale University School of Medicine, USA; 
      Department of Immunobiology, Yale University School of Medicine, USA.
FAU - Goldstein, Daniel R
AU  - Goldstein DR
LA  - eng
GR  - K02 AG033049/AG/NIA NIH HHS/United States
GR  - R01 AG028082/AG/NIA NIH HHS/United States
GR  - AG033049/AG/NIA NIH HHS/United States
GR  - AG028082/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130624
PL  - England
TA  - Curr Opin Immunol
JT  - Current opinion in immunology
JID - 8900118
SB  - IM
MH  - *Aging
MH  - Animals
MH  - *Antigen Presentation
MH  - Cell Differentiation
MH  - Dendritic Cells/cytology/*immunology
MH  - Humans
MH  - Inflammation/immunology
MH  - T-Lymphocytes/immunology
PMC - PMC3775944
MID - NIHMS490122
EDAT- 2013/06/29 06:00
MHDA- 2013/12/24 06:00
PMCR- 2014/08/01
CRDT- 2013/06/29 06:00
PHST- 2013/02/26 00:00 [received]
PHST- 2013/05/22 00:00 [revised]
PHST- 2013/05/28 00:00 [accepted]
PHST- 2013/06/29 06:00 [entrez]
PHST- 2013/06/29 06:00 [pubmed]
PHST- 2013/12/24 06:00 [medline]
PHST- 2014/08/01 00:00 [pmc-release]
AID - S0952-7915(13)00097-6 [pii]
AID - 10.1016/j.coi.2013.05.016 [doi]
PST - ppublish
SO  - Curr Opin Immunol. 2013 Aug;25(4):535-41. doi: 10.1016/j.coi.2013.05.016. Epub 
      2013 Jun 24.