PMID- 23806455
OWN - NLM
STAT- MEDLINE
DCOM- 20130903
LR  - 20231213
IS  - 1534-4436 (Electronic)
IS  - 1081-1206 (Linking)
VI  - 111
IP  - 1
DP  - 2013 Jul
TI  - Interpretation of food specific immunoglobulin E levels in the context of total 
      IgE.
PG  - 20-4
LID - S1081-1206(13)00346-3 [pii]
LID - 10.1016/j.anai.2013.05.012 [doi]
AB  - BACKGROUND: Food specific immunoglobulin E (IgE) (fsIgE) cut points are used in 
      the evaluation of food allergies. Concomitant measurement of total IgE (tIgE) is 
      traditionally not obtained. We anecdotally observed elevations in fsIgE mirroring 
      tIgE increases, which may confound accurate interpretation. OBJECTIVE: To 
      determine whether changes in tIgE were associated with fsIgE and whether 
      predictions of fsIgE could be formulated based on tIgE. METHODS: We studied 
      children younger than 18 years who had both tIgE and fsIgE (egg, n = 136; milk, 
      n = 123; peanut, n = 201; soy, n = 55) obtained simultaneously on 1 or more 
      occasion between January 2008 and February 2011. After institutional review board 
      approval, natural log-transformed (ln) tIgE and fsIgE levels were analyzed using 
      univariate and multivariate regression models to assess associations and predict 
      fsIgE using tIgE and other covariates. RESULTS: Soy IgE levels were strongly 
      correlated (rho = 0.85, P < .001), whereas egg, milk, and peanut IgE levels were 
      substantially correlated (rho = 0.69, 0.69, and 0.66, respectively, P < .001) with 
      tIgE. A 1-unit increase in ln(tIgE) was significantly correlated with unit 
      increases in ln(egg IgE) (0.77), ln(milk IgE) (0.84), ln(peanut IgE) (0.87), and 
      ln(soy IgE) (0.89) (P < .001). The ln(tIgE)-based univariate models could predict 
      fsIgE in the validation data with strong (soy) and substantial (egg, milk, and 
      peanut) predictive ability (P < .001). CONCLUSION: Our study found significant 
      and parallel relationships between tIgE and fsIgE levels to egg, milk, peanut, 
      and soy. It underscores the importance of examining fsIgE levels in context of 
      tIgE while making diagnostic and management decisions in children with food 
      allergies.
CI  - Copyright (c) 2013 American College of Allergy, Asthma & Immunology. Published by 
      Elsevier Inc. All rights reserved.
FAU - Federly, Tara J
AU  - Federly TJ
AD  - Children's Mercy Hospitals and Clinics, Kansas City, Missouri 64108, USA.
FAU - Jones, Bridgette L
AU  - Jones BL
FAU - Dai, Hongying
AU  - Dai H
FAU - Dinakar, Chitra
AU  - Dinakar C
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Allergy Asthma Immunol
JT  - Annals of allergy, asthma & immunology : official publication of the American 
      College of Allergy, Asthma, & Immunology
JID - 9503580
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/immunology
MH  - Animals
MH  - Child, Preschool
MH  - Egg Hypersensitivity/immunology
MH  - Female
MH  - Food Hypersensitivity/*immunology
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Milk/immunology
MH  - Milk Hypersensitivity/immunology
MH  - Ovum/immunology
MH  - Peanut Hypersensitivity/immunology
MH  - Skin Tests
MH  - Soy Foods
MH  - Glycine max/immunology
EDAT- 2013/06/29 06:00
MHDA- 2013/09/04 06:00
CRDT- 2013/06/29 06:00
PHST- 2013/04/03 00:00 [received]
PHST- 2013/05/13 00:00 [revised]
PHST- 2013/05/16 00:00 [accepted]
PHST- 2013/06/29 06:00 [entrez]
PHST- 2013/06/29 06:00 [pubmed]
PHST- 2013/09/04 06:00 [medline]
AID - S1081-1206(13)00346-3 [pii]
AID - 10.1016/j.anai.2013.05.012 [doi]
PST - ppublish
SO  - Ann Allergy Asthma Immunol. 2013 Jul;111(1):20-4. doi: 
      10.1016/j.anai.2013.05.012.