PMID- 23806777
OWN - NLM
STAT- MEDLINE
DCOM- 20131023
LR  - 20220408
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1526
DP  - 2013 Aug 14
TI  - Increased phosphorylation of mTOR is involved in remote ischemic preconditioning 
      of hippocampus in mice.
PG  - 94-101
LID - S0006-8993(13)00869-X [pii]
LID - 10.1016/j.brainres.2013.06.018 [doi]
AB  - Different signaling pathways are involved in tissue protection against ischemia 
      reperfusion (IR) injury, among them mammalian target of rapamycin (mTOR) and 
      related pathways have been examined in many recent studies. Present study 
      evaluated the role of mTOR in remote ischemic preconditioning (RIPC) of 
      hippocampus. Renal ischemia was induced (3 cycles of 5min occlusion and 5min 
      reperfusion of unilateral renal artery) 24h before global brain ischemia (20min 
      bilateral common carotid artery occlusion). Saline or rapamycin (mTOR inhibitor; 
      5mg/kg, i.p.) was injected 30min before RIPC. mTOR and phosphorylated mTOR 
      (p-mTOR) expression, superoxide dismutase (SOD) activity and retention trial of 
      passive avoidance test were determined 24h after global ischemia. Apoptosis and 
      neuronal cell density were assessed 72h after hippocampal ischemia. RIPC 
      decreased apoptosis (p<0.05 vs. IR), improved memory (p<0.05 vs. IR), and 
      augmented p-mTOR expression and SOD activity after hippocampal ischemia (p<0.05 
      vs. IR). Rapamycin abolished all protective effects of RIPC (p<0.05 vs. RIPC+IR) 
      suggesting a role for mTOR in RIPC induced hippocampal protection.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Zare Mehrjerdi, Fatemeh
AU  - Zare Mehrjerdi F
AD  - Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran.
FAU - Aboutaleb, Nahid
AU  - Aboutaleb N
FAU - Habibey, Rouhollah
AU  - Habibey R
FAU - Ajami, Marjan
AU  - Ajami M
FAU - Soleimani, Mansoureh
AU  - Soleimani M
FAU - Arabian, Maedeh
AU  - Arabian M
FAU - Niknazar, Somayeh
AU  - Niknazar S
FAU - Hossein Davoodi, Sayed
AU  - Hossein Davoodi S
FAU - Pazoki-Toroudi, Hamidreza
AU  - Pazoki-Toroudi H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130624
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - EC 2.7.1.1 (mTOR protein, mouse)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Blotting, Western
MH  - Brain Ischemia/*metabolism
MH  - Disease Models, Animal
MH  - Hippocampus/*blood supply/*metabolism
MH  - In Situ Nick-End Labeling
MH  - *Ischemic Preconditioning
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Phosphorylation
MH  - TOR Serine-Threonine Kinases/*metabolism
OTO - NOTNLM
OT  - ATP sensitive potassium channels
OT  - Apoptosis
OT  - CCA
OT  - Common carotid artery
OT  - IR
OT  - Ischemia reperfusion
OT  - KATP
OT  - MAPK
OT  - Mammalian target of rapamycin
OT  - Memory
OT  - Mitochondrial ATP sensitive potassium channels
OT  - Mitogen activated protein kinases
OT  - PAT
OT  - Passive avoidance test
OT  - RIPC
OT  - ROS
OT  - Rapa
OT  - Rapamycin
OT  - Reactive Oxygen Species
OT  - Remote ischemia preconditioning
OT  - Remote ischemic preconditioning
OT  - SOD
OT  - Superoxide dismutase
OT  - mKATP
OT  - mTOR
EDAT- 2013/06/29 06:00
MHDA- 2013/10/24 06:00
CRDT- 2013/06/29 06:00
PHST- 2013/03/04 00:00 [received]
PHST- 2013/06/12 00:00 [revised]
PHST- 2013/06/14 00:00 [accepted]
PHST- 2013/06/29 06:00 [entrez]
PHST- 2013/06/29 06:00 [pubmed]
PHST- 2013/10/24 06:00 [medline]
AID - S0006-8993(13)00869-X [pii]
AID - 10.1016/j.brainres.2013.06.018 [doi]
PST - ppublish
SO  - Brain Res. 2013 Aug 14;1526:94-101. doi: 10.1016/j.brainres.2013.06.018. Epub 
      2013 Jun 24.