PMID- 23806883
OWN - NLM
STAT- MEDLINE
DCOM- 20140121
LR  - 20130628
IS  - 2320-2890 (Electronic)
IS  - 2319-4170 (Linking)
VI  - 36
IP  - 3
DP  - 2013 May-Jun
TI  - Lower serum tropomyosin receptor kinase B levels in patients with schizophrenia.
PG  - 132-6
LID - 10.4103/2319-4170.113229 [doi]
AB  - BACKGROUND: Brain-derived neurotrophic factor (BDNF) and tropomyosin receptor 
      kinase B (TrkB) have previously been found to be reduced in the prefrontal cortex 
      of patients with schizophrenia. In this study, we tried to investigate the 
      protein levels of BDNF and TrkB from peripheral blood in the veins of individuals 
      with schizophrenia and health controls. METHODS: From January 2008 to November 
      2010, we recruited 40 schizophrenic patients and 56 healthy controls. Serum BDNF 
      and total TrkB protein levels were detected with enzyme-linked immunosorbent 
      assay (ELISA) kits. Outliners of BDNF and TrkB were excluded initially. Analysis 
      of covariance (ANCOVA) with age adjustment was used for group mean differences of 
      different groups. RESULTS: After using the ANCOVA with age adjustment, the 
      results of this work showed that BDNF presented no significant difference (F = 
      0.065, p = 0.800), but the serum TrkB protein level was significantly lower in 
      schizophrenic patients than in healthy controls (F = 8.34, p = 0.005). 
      CONCLUSION: Our findings showed a lower TrkB protein level in serum from 
      schizophrenia patients compared with healthy controls, indicating that the 
      signaling transmission of BDNF/TrkB may be affected in peripheral blood from 
      individuals with schizophrenia.
FAU - Hung, Yi-Yung
AU  - Hung YY
AD  - Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung 
      University College of Medicine, Kaohsiung, Taiwan.
FAU - Huang, Tiao-Lai
AU  - Huang TL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biomed J
JT  - Biomedical journal
JID - 101599820
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/blood/physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Receptor, trkB/*blood/physiology
MH  - Schizophrenia/*blood
MH  - Signal Transduction/physiology
EDAT- 2013/06/29 06:00
MHDA- 2014/01/22 06:00
CRDT- 2013/06/29 06:00
PHST- 2013/06/29 06:00 [entrez]
PHST- 2013/06/29 06:00 [pubmed]
PHST- 2014/01/22 06:00 [medline]
AID - BiomedJ_2013_36_3_132_113229 [pii]
AID - 10.4103/2319-4170.113229 [doi]
PST - ppublish
SO  - Biomed J. 2013 May-Jun;36(3):132-6. doi: 10.4103/2319-4170.113229.