PMID- 23807796
OWN - NLM
STAT- MEDLINE
DCOM- 20140123
LR  - 20211021
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Print)
IS  - 1064-3745 (Linking)
VI  - 1036
DP  - 2013
TI  - Clinical trials of cardiac repair with adult bone marrow- derived cells.
PG  - 179-205
LID - 10.1007/978-1-62703-511-8_15 [doi]
AB  - The past decade has witnessed a marked increase in the number of clinical trials 
      of cardiac repair with adult bone marrow cells (BMCs). These trials included 
      patients with acute myocardial infarction (MI) as well as chronic ischemic heart 
      disease (IHD) and utilized different types of BMCs with variable numbers, routes 
      of administration, and timings after MI. Given these differences in methods, the 
      outcomes from these trials have been often disparate and controversial. However, 
      analysis of pooled data suggests that BMC injection enhances left ventricular 
      function, reduces infarct scar size, and improves remodeling in patients with 
      acute MI as well as chronic IHD. BMC therapy also improves clinical outcomes 
      during follow-up without any increase in adverse effects. Although the underlying 
      mechanisms of heart repair are difficult to elucidate in human studies, valuable 
      insights may be gleaned from subgroup analysis of key variables. This information 
      may be utilized to design future randomized controlled trials to carefully 
      determine the long-term safety and benefits of BMC therapy.
FAU - Jeevanantham, Vinodh
AU  - Jeevanantham V
AD  - Division of Cardiovascular Diseases, Cardiovascular Research Institute, 
      University of Kansas Medical Center, Kansas City, KS, USA.
FAU - Afzal, Mohammad R
AU  - Afzal MR
FAU - Zuba-Surma, Ewa K
AU  - Zuba-Surma EK
FAU - Dawn, Buddhadeb
AU  - Dawn B
LA  - eng
GR  - R01 HL089939/HL/NHLBI NIH HHS/United States
GR  - R01 HL-89939/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
RN  - 0 (AC133 Antigen)
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, CD34)
RN  - 0 (Glycoproteins)
RN  - 0 (Peptides)
SB  - IM
MH  - AC133 Antigen
MH  - Acute Disease
MH  - Adult
MH  - Antigens, CD/metabolism
MH  - Antigens, CD34/metabolism
MH  - Bone Marrow Cells/*cytology
MH  - Bone Marrow Transplantation/*methods
MH  - Chronic Disease
MH  - *Clinical Trials as Topic
MH  - Glycoproteins/metabolism
MH  - Humans
MH  - Mesenchymal Stem Cells/*cytology
MH  - Meta-Analysis as Topic
MH  - Myocardial Infarction/*therapy
MH  - Myocardial Ischemia/*therapy
MH  - Peptides/metabolism
PMC - PMC4270749
MID - NIHMS648014
COIS- Conflict of Interest: None
EDAT- 2013/06/29 06:00
MHDA- 2014/01/24 06:00
PMCR- 2014/12/18
CRDT- 2013/06/29 06:00
PHST- 2013/06/29 06:00 [entrez]
PHST- 2013/06/29 06:00 [pubmed]
PHST- 2014/01/24 06:00 [medline]
PHST- 2014/12/18 00:00 [pmc-release]
AID - 10.1007/978-1-62703-511-8_15 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2013;1036:179-205. doi: 10.1007/978-1-62703-511-8_15.