PMID- 23807923
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130704
LR  - 20220331
IS  - 2233-6079 (Print)
IS  - 2233-6087 (Electronic)
IS  - 2233-6079 (Linking)
VI  - 37
IP  - 3
DP  - 2013 Jun
TI  - Effect of Green Tea Extract/Poly-gamma-Glutamic Acid Complex in Obese Type 2 Diabetic 
      Mice.
PG  - 196-206
LID - 10.4093/dmj.2013.37.3.196 [doi]
AB  - BACKGROUND: The increasing prevalence of type 2 diabetes mellitus (T2DM) is 
      associated with the rapid spread of obesity. Obesity induces insulin resistance, 
      resulting in beta-cell dysfunction and thus T2DM. Green tea extract (GTE) has been 
      known to prevent obesity and T2DM, but this effect is still being debated. Our 
      previous results suggested that circulating green tea gallated catechins (GCs) 
      hinders postprandial blood glucose lowering, regardless of reducing glucose and 
      cholesterol absorption when GCs are present in the intestinal lumen. This study 
      aimed to compare the effect of GTE with that of GTE coadministered with 
      poly-gamma-glutamic acid (gamma-PGA), which is likely to inhibit the intestinal 
      absorption of GCs. METHODS: The db/db mice and age-matched nondiabetic mice were 
      provided with normal chow diet containing GTE (1%), gamma-PGA (0.1%), or GTE+gamma-PGA 
      (1%:0.1%) for 4 weeks. RESULTS: In nondiabetic mice, none of the drugs showed any 
      effects after 4 weeks. In db/db mice, however, weight gain and body fat gain were 
      significantly reduced in the GTE+gamma-PGA group compared to nondrug-treated db/db 
      control mice without the corresponding changes in food intake and appetite. 
      Glucose intolerance was also ameliorated in the GTE+gamma-PGA group. 
      Histopathological analyses showed that GTE+gamma-PGA-treated db/db mice had a 
      significantly reduced incidence of fatty liver and decreased pancreatic islet 
      size. Neither GTE nor gamma-PGA treatment showed any significant results. CONCLUSION: 
      These results suggest that GTE+gamma-PGA treatment than GTE or gamma-PGA alone may be a 
      useful tool for preventing both obesity and obesity-induced T2DM.
FAU - Bae, Ki-Cheor
AU  - Bae KC
AD  - Department of Physiology, Keimyung University School of Medicine, Daegu, Korea.
FAU - Park, Jae-Hyung
AU  - Park JH
FAU - Na, Ann-Yae
AU  - Na AY
FAU - Kim, Sun-Joo
AU  - Kim SJ
FAU - Ahn, Shinbyoung
AU  - Ahn S
FAU - Kim, Sang-Pyo
AU  - Kim SP
FAU - Oh, Byung-Chul
AU  - Oh BC
FAU - Cho, Ho-Chan
AU  - Cho HC
FAU - Kim, Yong Woon
AU  - Kim YW
FAU - Song, Dae-Kyu
AU  - Song DK
LA  - eng
PT  - Journal Article
DEP - 20130614
PL  - Korea (South)
TA  - Diabetes Metab J
JT  - Diabetes & metabolism journal
JID - 101556588
PMC - PMC3689017
OTO - NOTNLM
OT  - Diabetes mellitus, type 2
OT  - Gallated catechins
OT  - Glucose intolerance
OT  - Obesity
OT  - Poly-gamma-glutamic acid
OT  - db/db mice
COIS- No potential conflict of interest relevant to this article was reported.
EDAT- 2013/06/29 06:00
MHDA- 2013/06/29 06:01
PMCR- 2013/06/01
CRDT- 2013/06/29 06:00
PHST- 2012/12/11 00:00 [received]
PHST- 2013/03/05 00:00 [accepted]
PHST- 2013/06/29 06:00 [entrez]
PHST- 2013/06/29 06:00 [pubmed]
PHST- 2013/06/29 06:01 [medline]
PHST- 2013/06/01 00:00 [pmc-release]
AID - 10.4093/dmj.2013.37.3.196 [doi]
PST - ppublish
SO  - Diabetes Metab J. 2013 Jun;37(3):196-206. doi: 10.4093/dmj.2013.37.3.196. Epub 
      2013 Jun 14.