PMID- 2380798
OWN - NLM
STAT- MEDLINE
DCOM- 19900907
LR  - 20211203
IS  - 0022-3166 (Print)
IS  - 0022-3166 (Linking)
VI  - 120
IP  - 8
DP  - 1990 Aug
TI  - Interactions of iron deficiency and exercise training relative to tissue 
      norepinephrine turnover, triiodothyronine production and metabolic rate in rats.
PG  - 900-8
AB  - The interactions of iron deficiency and exercise training relative to resting 
      metabolic rate (RMR), tissue norepinephrine (NE) turnover and triiodothyronine 
      (T3) production were examined in male Sprague-Dawley rats. Animals were assigned 
      to iron-deficient (ID) or control (CN) diets and to sedentary (SD) or 
      treadmill-exercise (EX) groups for 6 or 12 wk. Iron-deficient animals (hemoglobin 
      7.2 +/- 0.2 g 100 mL-1) had a 17% higher RMR and had slower growth rates than CN 
      animals. Exercise training affected growth but not RMR in iron deficiency. Oxygen 
      consumption (Vo2) following pharmacologic injection of norepinephrine was similar 
      in both iron-deficient and exercised groups despite a 35% lower maximal exercise 
      Vo2 in trained iron-deficient rats. NE turnover was lower in heart (55%) and 
      liver (80%) of iron-deficient animals relative to controls. Trained 
      iron-deficient animals had lower NE turnover in interscapular brown adipose 
      tissue (IBAT) than sedentary iron-deficient animals; however, training did not 
      alter NE turnover in control animals. In vitro liver and IBAT T3 production was 
      similar in all groups except for lower activities (40%) in 6-wk iron-deficient, 
      exercised animals. The significant effect of exercise on the growth attenuation 
      of iron-deficient, exercised animals is thus not explained by increased IBAT 
      metabolic activity or a generalized sympathetic nervous system activation. 
      Decreased T3 production during periods of rapid growth and lean body mass 
      development, however, may be important in exercised, iron-deficient animals.
FAU - Tobin, B W
AU  - Tobin BW
AD  - Nutrition Program, Noll Laboratory for Human Performance Research, Pennsylvania 
      State University, University Park 16802.
FAU - Beard, J L
AU  - Beard JL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Adipose Tissue, Brown/anatomy & histology/metabolism
MH  - Animals
MH  - Basal Metabolism
MH  - Body Weight
MH  - *Iron Deficiencies
MH  - Liver/anatomy & histology/metabolism
MH  - Male
MH  - Myocardium/metabolism
MH  - Norepinephrine/*metabolism
MH  - Organ Size
MH  - Oxidation-Reduction
MH  - Oxygen Consumption
MH  - *Physical Conditioning, Animal
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Triiodothyronine/*biosynthesis
EDAT- 1990/08/01 00:00
MHDA- 1990/08/01 00:01
CRDT- 1990/08/01 00:00
PHST- 1990/08/01 00:00 [pubmed]
PHST- 1990/08/01 00:01 [medline]
PHST- 1990/08/01 00:00 [entrez]
AID - 10.1093/jn/120.8.900 [doi]
PST - ppublish
SO  - J Nutr. 1990 Aug;120(8):900-8. doi: 10.1093/jn/120.8.900.