PMID- 23808319
OWN - NLM
STAT- MEDLINE
DCOM- 20130917
LR  - 20131121
IS  - 1341-8963 (Print)
IS  - 1341-8963 (Linking)
VI  - 48
IP  - 2
DP  - 2013 Apr
TI  - [Antibiotic drug minocycline: a potential therapeutic drug for 
      methamphetamine-related disorders].
PG  - 118-25
AB  - Accumulating evidence suggests a role of inflammation in the pathophysiology of a 
      number of neuropsychiatric diseases. The second generation antibiotic drug 
      minocycline has potent neuroprotective and anti-inflammatory effects. We reported 
      that minocycline could attenuate behavioral abnormalities and dopaminergic 
      neurotoxicity in mice after administration of methamphetamine or 
      3,4-methylenedioxymethamphetamine (MDMA). Furthermore, we reported that 
      minocycline was effective in the animal models of schizophrenia. Moreover, a 
      double-blind, placebo-control, cross-over study showed that minocycline was 
      effective in the rewarding effects in healthy human subjects. In this article, we 
      would like to discuss minocycline as a potential therapeutic drug for 
      methamphetamine-related disorders.
FAU - Hashimoto, Kenji
AU  - Hashimoto K
AD  - Division of Clinical Neuroscience, Chiba University Center for Forensic Mental 
      Health, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. 
      hashimoto@faculty.chiba-u.jp
FAU - Ishima, Tamaki
AU  - Ishima T
FAU - Fujita, Yuko
AU  - Fujita Y
FAU - Zhang, Lin
AU  - Zhang L
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nihon Arukoru Yakubutsu Igakkai Zasshi
JT  - Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & 
      drug dependence
JID - 9612304
RN  - 0 (Anti-Bacterial Agents)
RN  - 44RAL3456C (Methamphetamine)
RN  - FYY3R43WGO (Minocycline)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/chemistry/*therapeutic use
MH  - Clinical Trials as Topic
MH  - Humans
MH  - Methamphetamine/*toxicity
MH  - Minocycline/chemistry/*therapeutic use
MH  - Schizophrenia/*drug therapy
MH  - Substance-Related Disorders/*drug therapy
EDAT- 2013/07/03 06:00
MHDA- 2013/09/18 06:00
CRDT- 2013/07/02 06:00
PHST- 2013/07/02 06:00 [entrez]
PHST- 2013/07/03 06:00 [pubmed]
PHST- 2013/09/18 06:00 [medline]
PST - ppublish
SO  - Nihon Arukoru Yakubutsu Igakkai Zasshi. 2013 Apr;48(2):118-25.