PMID- 23809192
OWN - NLM
STAT- MEDLINE
DCOM- 20140207
LR  - 20220310
IS  - 1878-5883 (Electronic)
IS  - 0022-510X (Linking)
VI  - 331
IP  - 1-2
DP  - 2013 Aug 15
TI  - Vitamin D, parathyroid hormone and muscle impairment in myotonic dystrophies.
PG  - 132-5
LID - S0022-510X(13)00268-2 [pii]
LID - 10.1016/j.jns.2013.06.008 [doi]
AB  - Parathyroid function in Myotonic Dystrophy (DM) patients has been poorly 
      investigated. Parathyroid and muscle parameters were assessed in 31 male DM1 
      (44+/-2 years), 13 male DM2 (56+/-2 years) and 32 healthy controls. 
      Hyperparathyroidism was diagnosed in 18% of patients without differences between 
      DM types. In all DM patients, hyperparathyroidism was associated with 
      normocalcemia but one with hypercalcemia. DM patients presented significantly 
      higher PTH and lower vitamin D (25OHD) compared with controls, also considering 
      seasonality. Severe vitamin D deficiency (25OHD<10 ng/ml) was diagnosed in 40% 
      and hypovitaminosis D (25OHD<30 ng/ml) occurred in 88% of DM patients. About 
      one-third of DM1 presented hypophosphatemia associated with elevated PTH levels. 
      Serum 25OHD levels negatively correlated with PTH and with body fat mass. 
      Considering DM1 patients, serum PTH levels positively correlated with CTG triplet 
      repeats. Furthermore, PTH levels negatively correlated with total modified 
      Medical Research Council (MRC) and positively with Muscular Impairment Rating 
      Scale (MIRS). By contrast, in DM2 patients muscle assessment did not show any 
      correlation with parathyroid function. In conclusion, we arrived at the 
      following: 1) severe vitamin D deficiency is common in DM patients and it is 
      associated with secondary hyperparathyroidism; 2) primary hyperparathyroidism, 
      though rare, may occur; 3) increased adiposity in DM may be a risk factor for 
      hypovitaminosis D; and 4) high serum PTH levels may indicate a muscle impairment, 
      at least in DM1.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Passeri, E
AU  - Passeri E
AD  - Endocrinology and Diabetology Unit, Dept. of Biomedical Sciences for Health, 
      University of Milan, Milan, Italy. elenapasseri83@libero.it
FAU - Bugiardini, E
AU  - Bugiardini E
FAU - Sansone, V A
AU  - Sansone VA
FAU - Valaperta, R
AU  - Valaperta R
FAU - Costa, E
AU  - Costa E
FAU - Ambrosi, B
AU  - Ambrosi B
FAU - Meola, G
AU  - Meola G
FAU - Corbetta, S
AU  - Corbetta S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130625
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
RN  - 0 (Parathyroid Hormone)
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Adult
MH  - Body Mass Index
MH  - Humans
MH  - Hyperparathyroidism, Secondary/*etiology
MH  - Male
MH  - Middle Aged
MH  - Muscle, Skeletal/*pathology/physiopathology
MH  - *Myotonic Dystrophy/blood/complications/pathology
MH  - Parathyroid Glands/pathology
MH  - Parathyroid Hormone/blood
MH  - Severity of Illness Index
MH  - Statistics as Topic
MH  - Statistics, Nonparametric
MH  - Vitamin D/blood
MH  - Vitamin D Deficiency/*etiology
OTO - NOTNLM
OT  - 25OHD
OT  - CTG correlations
OT  - Calcium
OT  - Myotonic Dystrophy type 1
OT  - Myotonic Dystrophy type 2
OT  - PTH
OT  - Phosphate
EDAT- 2013/07/03 06:00
MHDA- 2014/02/08 06:00
CRDT- 2013/07/02 06:00
PHST- 2013/02/21 00:00 [received]
PHST- 2013/05/15 00:00 [revised]
PHST- 2013/06/07 00:00 [accepted]
PHST- 2013/07/02 06:00 [entrez]
PHST- 2013/07/03 06:00 [pubmed]
PHST- 2014/02/08 06:00 [medline]
AID - S0022-510X(13)00268-2 [pii]
AID - 10.1016/j.jns.2013.06.008 [doi]
PST - ppublish
SO  - J Neurol Sci. 2013 Aug 15;331(1-2):132-5. doi: 10.1016/j.jns.2013.06.008. Epub 
      2013 Jun 25.