PMID- 23809502
OWN - NLM
STAT- MEDLINE
DCOM- 20140311
LR  - 20220321
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 100
IP  - 4
DP  - 2013 Oct
TI  - Age thresholds for changes in semen parameters in men.
PG  - 952-8
LID - S0015-0282(13)00687-0 [pii]
LID - 10.1016/j.fertnstert.2013.05.046 [doi]
AB  - OBJECTIVE: To determine whether age thresholds for elements of semen quality 
      exist. DESIGN: Retrospective analysis (covariance and point-change analysis) of 
      results of 4,822 semen analyses and 259 fluorescence in situ hybridization (FISH) 
      analyses. SETTING: Reference laboratory within an infertility clinic. PATIENT(S): 
      A total of 5,081 men aged 16.5-72.3 years. INTERVENTION(S): None. MAIN OUTCOME 
      MEASURE(S): Ejaculate volume, sperm concentration, sperm motility, sperm motion 
      parameters, strict morphology, and results of FISH analysis. RESULT(S): Measured 
      parameters of ejaculates did not change before 34 years of age. Immediately 
      thereafter, total sperm numbers (and total motile) declined. Sperm concentration 
      and the proportion of sperm of normal morphology declined after 40 years. Sperm 
      motility and progressive parameters of motile sperm fell after 43 years and 
      ejaculate volume after 45 years. The ratio of Y:X-bearing sperm in ejaculates 
      decreased only after 55 years. CONCLUSION(S): Our findings project a declining 
      likelihood of pregnancy following intercourse with men >34 years old, independent 
      from the woman's age and increasing with advancing age. Age-related mechanisms 
      associated with this oligoasthenoteratozoospermic progression are discussed.
CI  - Copyright (c) 2013 American Society for Reproductive Medicine. Published by 
      Elsevier Inc. All rights reserved.
FAU - Stone, Bronte A
AU  - Stone BA
AD  - Reproductive Technology Laboratories, Los Angeles, California; Utah Fertility 
      Partners, Pleasant Grove, Utah. Electronic address: 
      bstone@californiafertilitypartners.com.
FAU - Alex, Allyse
AU  - Alex A
FAU - Werlin, Lawrence B
AU  - Werlin LB
FAU - Marrs, Richard P
AU  - Marrs RP
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20130627
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
SB  - IM
CIN - J Urol. 2014 May;191(5):1356. PMID: 24745525
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aging/genetics/*pathology
MH  - Analysis of Variance
MH  - Cell Shape
MH  - Chromosomes, Human, X
MH  - Chromosomes, Human, Y
MH  - Female
MH  - Fertility
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infertility, Male/genetics/pathology/physiopathology
MH  - Least-Squares Analysis
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - *Paternal Age
MH  - Pregnancy
MH  - Pregnancy Outcome
MH  - Retrospective Studies
MH  - Risk Factors
MH  - *Semen Analysis/methods
MH  - Sperm Count
MH  - Sperm Motility
MH  - Spermatozoa/*pathology
MH  - Young Adult
OTO - NOTNLM
OT  - Aging and oligoasthenoteratozoospermia
OT  - CASA
OT  - human semen
OT  - primary sex ratio
OT  - sperm morphology
EDAT- 2013/07/03 06:00
MHDA- 2014/03/13 06:00
CRDT- 2013/07/02 06:00
PHST- 2013/02/19 00:00 [received]
PHST- 2013/05/20 00:00 [revised]
PHST- 2013/05/30 00:00 [accepted]
PHST- 2013/07/02 06:00 [entrez]
PHST- 2013/07/03 06:00 [pubmed]
PHST- 2014/03/13 06:00 [medline]
AID - S0015-0282(13)00687-0 [pii]
AID - 10.1016/j.fertnstert.2013.05.046 [doi]
PST - ppublish
SO  - Fertil Steril. 2013 Oct;100(4):952-8. doi: 10.1016/j.fertnstert.2013.05.046. Epub 
      2013 Jun 27.