PMID- 23809509
OWN - NLM
STAT- MEDLINE
DCOM- 20140821
LR  - 20131223
IS  - 1873-5010 (Electronic)
IS  - 1569-1993 (Linking)
VI  - 13
IP  - 1
DP  - 2014 Jan
TI  - Reduced fat oxidation rates during submaximal exercise in boys with cystic 
      fibrosis.
PG  - 92-8
LID - S1569-1993(13)00105-7 [pii]
LID - 10.1016/j.jcf.2013.05.014 [doi]
AB  - BACKGROUND: Exercise is a viable form of therapy for children with cystic 
      fibrosis (CF). Understanding the energy sources used during exercise would aid CF 
      patients in obtaining proper nutrition in order to sustain an active lifestyle. 
      METHODS: Six boys with CF (mean age +/- SD: 14.8 +/- 2.3 yrs, FEV1: 99 +/- 18% 
      predicted) and six matched controls (14.0 +/- 2.2 yrs) completed a session of two 
      30 min bouts of cycling at an intensity set at 50% peak mechanical power. Rates 
      of total fat and carbohydrate (CHO) oxidation were calculated from expired gases. 
      Plasma insulin, glucose and free fatty acid (FFA) were determined before, during 
      and at the end of the exercise. RESULTS: Rates of fat oxidation (expressed in 
      mean mg x kg body weight(-1) x min(-1) +/- SD) were significantly lower in children 
      with CF (5.7 +/- 1.6) compared to controls (8.6 +/- 1.8, p < 0.05). Children with CF 
      also had lower values than controls in amount of fat oxidized (CF: 17.3 +/- 5.0 g, 
      controls: 26.1 +/- 5.9 g, p < 0.05) and percent of total energy expenditure from 
      fat (CF: 32 +/- 6%, controls: 43 +/- 7%, p < .0.05), but a higher contribution from 
      CHO (CF: 68 +/- 6%, controls: 57 +/- 7% p < .0.05). Plasma FFA was significantly 
      lower in children with CF compared to controls during (CF: 252.5 +/- 117.9 muM, 
      controls: 602.2 +/- 295.6) and at the end of exercise (CF: 430.9 +/- 180.6, controls: 
      1147.5 +/- 473.5). There were no differences in the rates of CHO oxidation, insulin 
      or glucose between groups. CONCLUSION: Fat metabolism during exercise is impaired 
      in boys with CF and may be attributed to an inability to mobilize FFA.
CI  - Copyright (c) 2013 European Cystic Fibrosis Society. Published by Elsevier B.V. All 
      rights reserved.
FAU - Nguyen, Thanh
AU  - Nguyen T
AD  - Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster 
      University, Hamilton, ON, Canada.
FAU - Obeid, Joyce
AU  - Obeid J
AD  - Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster 
      University, Hamilton, ON, Canada.
FAU - Baker, Jeff M
AU  - Baker JM
AD  - Exercise Metabolism Research Group, Department of Kinesiology, McMaster 
      University, Hamilton, ON, Canada; Department of Kinesiology, McMaster University, 
      Hamilton, ON, Canada.
FAU - Takken, Tim
AU  - Takken T
AD  - Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster 
      University, Hamilton, ON, Canada; Wilhelmina Children's Hospital, University 
      Medical Center Utrecht, Utrecht, The Netherlands.
FAU - Pedder, Linda
AU  - Pedder L
AD  - Cystic Fibrosis Clinic, McMaster Children's Hospital, Hamilton, ON, Canada.
FAU - Parise, Gianni
AU  - Parise G
AD  - Exercise Metabolism Research Group, Department of Kinesiology, McMaster 
      University, Hamilton, ON, Canada; Department of Kinesiology, McMaster University, 
      Hamilton, ON, Canada.
FAU - Timmons, Brian W
AU  - Timmons BW
AD  - Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster 
      University, Hamilton, ON, Canada. Electronic address: timmonbw@mcmaster.ca.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130701
PL  - Netherlands
TA  - J Cyst Fibros
JT  - Journal of cystic fibrosis : official journal of the European Cystic Fibrosis 
      Society
JID - 101128966
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Insulin)
SB  - IM
MH  - Adolescent
MH  - Bicycling
MH  - Blood Glucose/metabolism
MH  - Child
MH  - Cystic Fibrosis/*metabolism/*physiopathology
MH  - Dietary Carbohydrates/metabolism
MH  - Dietary Fats/*metabolism
MH  - Energy Metabolism/physiology
MH  - Exercise/*physiology
MH  - Fatty Acids, Nonesterified/metabolism
MH  - Humans
MH  - Insulin/blood
MH  - Life
MH  - Lipid Metabolism/physiology
MH  - Male
MH  - Models, Biological
MH  - Nutritional Status
MH  - Oxidation-Reduction
MH  - Oxygen Consumption/physiology
OTO - NOTNLM
OT  - Cycling
OT  - Cystic fibrosis
OT  - Free fatty acids
OT  - Substrate utilization
EDAT- 2013/07/03 06:00
MHDA- 2014/08/22 06:00
CRDT- 2013/07/02 06:00
PHST- 2013/01/31 00:00 [received]
PHST- 2013/05/13 00:00 [revised]
PHST- 2013/05/15 00:00 [accepted]
PHST- 2013/07/02 06:00 [entrez]
PHST- 2013/07/03 06:00 [pubmed]
PHST- 2014/08/22 06:00 [medline]
AID - S1569-1993(13)00105-7 [pii]
AID - 10.1016/j.jcf.2013.05.014 [doi]
PST - ppublish
SO  - J Cyst Fibros. 2014 Jan;13(1):92-8. doi: 10.1016/j.jcf.2013.05.014. Epub 2013 Jul 
      1.