PMID- 23811071
OWN - NLM
STAT- MEDLINE
DCOM- 20131231
LR  - 20211021
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 248
DP  - 2013 Sep 17
TI  - Exercise facilitates the action of dietary DHA on functional recovery after brain 
      trauma.
PG  - 655-63
LID - S0306-4522(13)00547-2 [pii]
LID - 10.1016/j.neuroscience.2013.06.041 [doi]
AB  - The abilities of docosahexaenoic acid (DHA) and exercise to counteract cognitive 
      decay after traumatic brain injury (TBI) is getting increasing recognition; 
      however, the possibility that these actions can be complementary remains just as 
      an intriguing possibility. Here we have examined the likelihood that the 
      combination of diet and exercise has the added potential to facilitate functional 
      recovery following TBI. Rats received mild fluid percussion injury (mFPI) or sham 
      injury and then were maintained on a diet high in DHA (1.2% DHA) with or without 
      voluntary exercise for 12days. We found that FPI reduced DHA content in the 
      brain, which was accompanied by increased levels of lipid peroxidation assessed 
      using 4-hydroxy-2-hexenal (4-HHE). FPI reduced the enzymes acyl-CoA oxidase 1 
      (Acox1) and 17beta-hydroxysteroid dehydrogenase type 4 (17beta-HSD4), and the 
      calcium-independent phospholipases A2 (iPLA2), which are involved in metabolism 
      of membrane phospholipids. FPI reduced levels of syntaxin-3 (STX-3), involved in 
      the action of membrane DHA on synaptic membrane expansion, and also reduced 
      brain-derived neurotrophic factor (BDNF) signaling through its tyrosine kinase B 
      (TrkB) receptor. These effects of FPI were optimally counteracted by the 
      combination of DHA and exercise. Our results support the possibility that the 
      complementary action of exercise is exerted on restoring membrane homeostasis 
      after TBI, which is necessary for supporting synaptic plasticity and cognition. 
      It is our contention that strategies that take advantage of the combined 
      applications of diet and exercise may have additional effects to the injured 
      brain.
CI  - Copyright (c) 2013 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Wu, A
AU  - Wu A
AD  - Department of Integrative Biology and Physiology, University of California at Los 
      Angeles, 621 Charles E. Young Drive, Los Angeles, CA 90095, USA. agwu@ucla.edu
FAU - Ying, Z
AU  - Ying Z
FAU - Gomez-Pinilla, F
AU  - Gomez-Pinilla F
LA  - eng
GR  - R01 NS050465/NS/NINDS NIH HHS/United States
GR  - NS50465/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20130628
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Qa-SNARE Proteins)
RN  - 25167-62-8 (Docosahexaenoic Acids)
RN  - EC 1.3.3.6 (Acyl-CoA Oxidase)
RN  - EC 3.1.1.4 (Phospholipases A2, Calcium-Independent)
RN  - EC 4.2.1.107 (Peroxisomal Multifunctional Protein-2)
SB  - IM
MH  - Acyl-CoA Oxidase/*metabolism
MH  - Animals
MH  - Brain Injuries/diet therapy/physiopathology/*therapy
MH  - Cognition/drug effects
MH  - Combined Modality Therapy
MH  - Docosahexaenoic Acids/*administration & dosage/metabolism/therapeutic use
MH  - *Exercise Therapy
MH  - Maze Learning/drug effects
MH  - Neuronal Plasticity/drug effects
MH  - Oxidative Stress/physiology
MH  - Peroxisomal Multifunctional Protein-2/*metabolism
MH  - Phospholipases A2, Calcium-Independent/*metabolism
MH  - Qa-SNARE Proteins/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - *Recovery of Function
MH  - Synapses/drug effects
PMC - PMC3951948
MID - NIHMS510007
OTO - NOTNLM
OT  - 17beta-HSD4
OT  - 17beta-hydroxysteroid dehydrogenase type 4
OT  - ANOVA
OT  - Acox1
OT  - BDNF
OT  - CTL
OT  - DHA
OT  - Exc
OT  - FAME
OT  - FPI
OT  - GC
OT  - MWZ
OT  - Morris water maze
OT  - RGD
OT  - STX-3
OT  - Sed
OT  - TBI
OT  - acyl-CoA oxidase 1
OT  - analysis of variance
OT  - calcium-independent phospholipase A2
OT  - cognition
OT  - control
OT  - docosahexaenoic acid
OT  - exercise
OT  - fatty acid methyl esters
OT  - fluid percussion injury
OT  - gas chromatography
OT  - iPLA2
OT  - omega-3 fatty acids
OT  - regular diet
OT  - sedentary
OT  - syntaxin 3
OT  - traumatic brain injury
EDAT- 2013/07/03 06:00
MHDA- 2014/01/01 06:00
PMCR- 2014/09/17
CRDT- 2013/07/02 06:00
PHST- 2013/05/07 00:00 [received]
PHST- 2013/06/11 00:00 [revised]
PHST- 2013/06/19 00:00 [accepted]
PHST- 2013/07/02 06:00 [entrez]
PHST- 2013/07/03 06:00 [pubmed]
PHST- 2014/01/01 06:00 [medline]
PHST- 2014/09/17 00:00 [pmc-release]
AID - S0306-4522(13)00547-2 [pii]
AID - 10.1016/j.neuroscience.2013.06.041 [doi]
PST - ppublish
SO  - Neuroscience. 2013 Sep 17;248:655-63. doi: 10.1016/j.neuroscience.2013.06.041. 
      Epub 2013 Jun 28.