PMID- 23812866
OWN - NLM
STAT- MEDLINE
DCOM- 20140505
LR  - 20211021
IS  - 1435-165X (Electronic)
IS  - 1018-8827 (Linking)
VI  - 23
IP  - 3
DP  - 2014 Mar
TI  - Serum brain-derived neurotrophic factor (BDNF) levels in attention 
      deficit-hyperactivity disorder (ADHD).
PG  - 173-7
LID - 10.1007/s00787-013-0447-1 [doi]
AB  - It has been proposed that the neurotrophin brain-derived neurotrophic factor 
      (BDNF) may be involved in attention deficit-hyperactivity disorder (ADHD) 
      etiopathogenesis. Alterations in BDNF serum levels have been observed in 
      childhood/adulthood neurodevelopmental pathologies, but no evidence is available 
      for BDNF serum concentrations in ADHD. The study includes 45 drug-naive ADHD 
      children and 45 age-sex matched healthy subjects. Concentration of serum BDNF was 
      determined by the ELISA method. BDNF serum levels in patients with ADHD were not 
      different from those of controls (mean +/- SD; ADHD: 39.33 +/- 10.41 ng/ml; controls: 
      38.82 +/- 8.29 ng/ml, t = -0.26, p = 0.80). Our findings indicate no alteration of 
      serum BDNF levels in untreated patients with ADHD. A further stratification for 
      cognitive, neuropsychological and psychopathological assessment in a larger 
      sample could be useful to clarify the role of BDNF in the endophenotype 
      characterization of ADHD.
FAU - Scassellati, Catia
AU  - Scassellati C
AD  - IRCCS "Centro S. Giovanni di Dio" Fatebenefratelli, Via Pilastroni 4, 25123, 
      Brescia, Italy, cscassellati@fatebenefratelli.it.
FAU - Zanardini, Roberta
AU  - Zanardini R
FAU - Tiberti, Alessandra
AU  - Tiberti A
FAU - Pezzani, Marco
AU  - Pezzani M
FAU - Valenti, Vera
AU  - Valenti V
FAU - Effedri, Paola
AU  - Effedri P
FAU - Filippini, Elena
AU  - Filippini E
FAU - Conte, Stefano
AU  - Conte S
FAU - Ottolini, Alberto
AU  - Ottolini A
FAU - Gennarelli, Massimo
AU  - Gennarelli M
FAU - Bocchio-Chiavetto, Luisella
AU  - Bocchio-Chiavetto L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130628
PL  - Germany
TA  - Eur Child Adolesc Psychiatry
JT  - European child & adolescent psychiatry
JID - 9212296
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adolescent
MH  - Attention Deficit Disorder with Hyperactivity/*blood/diagnosis
MH  - Body Mass Index
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Child
MH  - Female
MH  - Humans
MH  - Male
MH  - Socioeconomic Factors
EDAT- 2013/07/03 06:00
MHDA- 2014/05/06 06:00
CRDT- 2013/07/02 06:00
PHST- 2013/02/22 00:00 [received]
PHST- 2013/06/21 00:00 [accepted]
PHST- 2013/07/02 06:00 [entrez]
PHST- 2013/07/03 06:00 [pubmed]
PHST- 2014/05/06 06:00 [medline]
AID - 10.1007/s00787-013-0447-1 [doi]
PST - ppublish
SO  - Eur Child Adolesc Psychiatry. 2014 Mar;23(3):173-7. doi: 
      10.1007/s00787-013-0447-1. Epub 2013 Jun 28.