PMID- 23813845
OWN - NLM
STAT- MEDLINE
DCOM- 20130927
LR  - 20130722
IS  - 1468-201X (Electronic)
IS  - 1355-6037 (Linking)
VI  - 99
IP  - 16
DP  - 2013 Aug
TI  - Prophylactic implantable cardioverter defibrillator treatment in patients with 
      end-stage heart failure awaiting heart transplantation.
PG  - 1158-65
LID - 10.1136/heartjnl-2013-304185 [doi]
AB  - OBJECTIVES: This study was designed to delineate the role of implantable 
      cardioverter defibrillator (ICD) therapy for the primary and secondary prevention 
      of sudden cardiac death in patients listed for heart transplantation. SETTING: 
      Retrospective observational multicentre study. PATIENTS: 1089 consecutive 
      patients listed for heart transplantation in two tertiary heart transplant 
      centres were enrolled. Of 550 patients (51%) on the transplant list with an ICD, 
      216 had received their ICD for the primary prevention of sudden cardiac death and 
      334 for secondary prevention. 539 patients did not receive an ICD. INTERVENTION: 
      Treatment with or without an ICD was left to the discretion of the heart failure 
      specialist. MAIN OUTCOME MEASURE: All-cause mortality. RESULTS: ICDs appear to be 
      associated with a reduction in all-cause mortality in patients implanted with the 
      device for primary and secondary prevention compared to those without an ICD 
      despite a median time on the waiting list of only 8 months (estimated 1-year: 
      88+/-3% vs. 77+/-3% vs. 67+/-3%; p=0.0001). A Cox regressional hazard model (corrected 
      for age, sex, underlying heart disease, atrial fibrillation, cardiac 
      resynchronisation therapy, New York Heart Association (NYHA) class, ejection 
      fraction, co-medication and year of listing) suggested an independent beneficial 
      effect of ICDs that was most pronounced in patients who had received an ICD for 
      primary prevention (HR 0.4, 95% CI 0.19 to 0.85; p=0.016). CONCLUSIONS: ICD 
      implantation appears to be associated with an immediate and sustained survival 
      benefit for patients awaiting heart transplantation.
FAU - Frohlich, Georg M
AU  - Frohlich GM
AD  - Cardiovascular Division, University Hospital Zurich, Raemistrasse 100, Zurich 
      CH-8091, Switzerland.
FAU - Holzmeister, Johannes
AU  - Holzmeister J
FAU - Hubler, Michael
AU  - Hubler M
FAU - Hubler, Samira
AU  - Hubler S
FAU - Wolfrum, Mathias
AU  - Wolfrum M
FAU - Enseleit, Frank
AU  - Enseleit F
FAU - Seifert, Burkhardt
AU  - Seifert B
FAU - Hurlimann, David
AU  - Hurlimann D
FAU - Lehmkuhl, Hans B
AU  - Lehmkuhl HB
FAU - Noll, Georg
AU  - Noll G
FAU - Steffel, Jan
AU  - Steffel J
FAU - Falk, Volkmar
AU  - Falk V
FAU - Luscher, Thomas F
AU  - Luscher TF
FAU - Hetzer, Roland
AU  - Hetzer R
FAU - Ruschitzka, Frank
AU  - Ruschitzka F
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20130627
PL  - England
TA  - Heart
JT  - Heart (British Cardiac Society)
JID - 9602087
SB  - IM
MH  - Adult
MH  - Arrhythmias, Cardiac/diagnosis/etiology/mortality/*prevention & control
MH  - Death, Sudden, Cardiac/etiology/*prevention & control
MH  - *Defibrillators, Implantable
MH  - Electric Countershock/adverse effects/*instrumentation/mortality
MH  - Female
MH  - Germany
MH  - Heart Failure/complications/diagnosis/mortality/surgery/*therapy
MH  - *Heart Transplantation
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Primary Prevention/*instrumentation/methods
MH  - Propensity Score
MH  - Proportional Hazards Models
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Secondary Prevention/*instrumentation/methods
MH  - Switzerland
MH  - Tertiary Care Centers
MH  - Time Factors
MH  - Treatment Outcome
MH  - *Waiting Lists/mortality
EDAT- 2013/07/03 06:00
MHDA- 2013/09/28 06:00
CRDT- 2013/07/02 06:00
PHST- 2013/07/02 06:00 [entrez]
PHST- 2013/07/03 06:00 [pubmed]
PHST- 2013/09/28 06:00 [medline]
AID - heartjnl-2013-304185 [pii]
AID - 10.1136/heartjnl-2013-304185 [doi]
PST - ppublish
SO  - Heart. 2013 Aug;99(16):1158-65. doi: 10.1136/heartjnl-2013-304185. Epub 2013 Jun 
      27.