PMID- 23814473
OWN - NLM
STAT- MEDLINE
DCOM- 20140203
LR  - 20211021
IS  - 1976-555X (Electronic)
IS  - 1229-845X (Print)
IS  - 1229-845X (Linking)
VI  - 14
IP  - 2
DP  - 2013
TI  - Clinical use of a ceramide-based moisturizer for treating dogs with atopic 
      dermatitis.
PG  - 199-205
LID - 10.4142/jvs.2013.14.2.199 [doi]
AB  - In humans, skin barrier dysfunction is thought to be responsible for enhanced 
      penetration of allergens. Similar to conditions seen in humans, canine atopic 
      dermatitis (CAD) is characterized by derangement of corneocytes and 
      disorganization of intercellular lipids in the stratum corenum (SC) with 
      decreased ceramide levels. This study was designed to evaluate the effects of a 
      moisturizer containing ceramide on dogs with CAD. Dogs (n = 20, 3~8 years old) 
      with mild to moderate clinical signs were recruited and applied a moisturizer 
      containing ceramide for 4 weeks. Transepidermal water loss (TEWL), skin 
      hydration, pruritus index for canine atopic dermatitis (PICAD) scores, and canine 
      atopic dermatitis extent and severity index (CADESI) scores of all dogs were 
      evaluated. Skin samples from five dogs were also examined with transmission 
      electron microscopy (TEM) using ruthenium tetroxide. TEWL, PICAD, and CADESI 
      values decreased (p < 0.05) and skin hydration increased dramatically over time 
      (p < 0.05). Electron micrographs showed that the skin barrier of all five dogs 
      was partially restored (p < 0.05). In conclusion, these results demonstrated that 
      moisturizer containing ceramide was effective for treating skin barrier 
      dysfunction and CAD symptoms.
FAU - Jung, Ji-young
AU  - Jung JY
AD  - College of Veterinary Medicine and Research Institute for Veterinary Science, 
      Seoul National University, Seoul 151-742, Korea.
FAU - Nam, Eui-hwa
AU  - Nam EH
FAU - Park, Seol-hee
AU  - Park SH
FAU - Han, Seung-hee
AU  - Han SH
FAU - Hwang, Cheol-yong
AU  - Hwang CY
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20130621
PL  - Korea (South)
TA  - J Vet Sci
JT  - Journal of veterinary science
JID - 100964185
RN  - 0 (Ceramides)
RN  - 0 (Emollients)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Ruthenium Compounds)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - 97E960G9RP (ruthenium tetraoxide)
SB  - IM
MH  - Animals
MH  - Ceramides/*therapeutic use
MH  - Cholesterol/*therapeutic use
MH  - Dermatitis, Atopic/complications/drug therapy/physiopathology/*veterinary
MH  - Dog Diseases/*drug therapy/etiology/physiopathology
MH  - Dogs
MH  - Emollients/*therapeutic use
MH  - Epidermis/drug effects/physiopathology/ultrastructure
MH  - Fatty Acids, Nonesterified/*therapeutic use
MH  - Female
MH  - Male
MH  - Microscopy, Electron, Transmission/veterinary
MH  - Pruritus/drug therapy/etiology/physiopathology/veterinary
MH  - Republic of Korea
MH  - Ruthenium Compounds/chemistry
MH  - Water Loss, Insensible/drug effects
PMC - PMC3694192
OTO - NOTNLM
OT  - atopic dermatitis
OT  - ceramide
OT  - dog
OT  - skin barrier dysfunction
OT  - transmission electron microscopy
EDAT- 2013/07/03 06:00
MHDA- 2014/02/04 06:00
PMCR- 2013/06/01
CRDT- 2013/07/02 06:00
PHST- 2012/05/18 00:00 [received]
PHST- 2012/09/30 00:00 [revised]
PHST- 2012/10/23 00:00 [accepted]
PHST- 2013/07/02 06:00 [entrez]
PHST- 2013/07/03 06:00 [pubmed]
PHST- 2014/02/04 06:00 [medline]
PHST- 2013/06/01 00:00 [pmc-release]
AID - 10.4142/jvs.2013.14.2.199 [doi]
PST - ppublish
SO  - J Vet Sci. 2013;14(2):199-205. doi: 10.4142/jvs.2013.14.2.199. Epub 2013 Jun 21.