PMID- 23815923
OWN - NLM
STAT- MEDLINE
DCOM- 20140505
LR  - 20211203
IS  - 1009-2137 (Print)
IS  - 1009-2137 (Linking)
VI  - 21
IP  - 3
DP  - 2013 Jun
TI  - [Relationship between HLA-A, B alleles and red blood cell parameters of patients 
      with --(SEA/alphaalpha) subtype of alpha(0)-thalassemia of Han ethnic population of Wuzhou 
      city].
PG  - 688-91
LID - 10.7534/j.issn.1009-2137.2013.03.030 [doi]
AB  - This study was purposed to investigate the relationship between HLA-A, B allele 
      polymorphisms and red blood cell parameters of patients with --(SEA/alphaalpha) subtype 
      of alpha(0)-thalassemia in Han ethnic population of Wuzhou city. The HLA genetic 
      polymorphisms were determined by polymerase chain reaction-sequence-based typing 
      (PCR-SBT) in 57 patients with --(SEA/alphaalpha) subtype of alpha(0)-thalassemia of Han 
      ethnic population in Wuzhou city, Guangxi province, China. Mean corpuscular 
      volume (MCV), hemoglobin (Hb), mean corpuscular hemoglobin (MCH) and mean 
      corpuscular hemoglobin concentration (MCHC) were detected by automatic blood 
      analyzer system. HbA2 were detected by electrophoretic method. The statistical 
      analysis was performed by ordinal polytomous logistic regression. The results 
      showed that Hb and HbA2 levels were significantly lower in patients positive for 
      HLA-A*33:03, B*15:01 or B*55:02, and were significantly higher in patients 
      positive for B*15:02 (P < 0.05). It is concluded that several HLA alleles may be 
      associated with Hb level of --(SEA/alphaalpha) subtype of alpha(0)-thalassemia of Han ethnic 
      population in Wuzhou city. This result has the value for understanding 
      phenotype-genotype relationships in thalassemia.
FAU - Chen, Xiu-Qun
AU  - Chen XQ
AD  - Wuzhou Red Cross Hospital, Guangxi Province, China.
FAU - Li, Jun
AU  - Li J
FAU - Cai, Yong-Lin
AU  - Cai YL
FAU - Li, Chuan-Jie
AU  - Li CJ
FAU - Ma, Yu-Yi
AU  - Ma YY
FAU - Huang, De-Wang
AU  - Huang DW
FAU - Li, Hai-Feng
AU  - Li HF
FAU - Lu, Ai-Ying
AU  - Lu AY
FAU - Tang, Min-Zhong
AU  - Tang MZ
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Shi Yan Xue Ye Xue Za Zhi
JT  - Zhongguo shi yan xue ye xue za zhi
JID - 101084424
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (Hemoglobins, Abnormal)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Child
MH  - Child, Preschool
MH  - China/epidemiology
MH  - Erythrocytes/*cytology
MH  - Ethnicity/genetics
MH  - Female
MH  - Genotype
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - Hemoglobins, Abnormal/genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Young Adult
MH  - alpha-Thalassemia/*blood/classification/epidemiology/*genetics
EDAT- 2013/07/03 06:00
MHDA- 2014/05/06 06:00
CRDT- 2013/07/03 06:00
PHST- 2013/07/03 06:00 [entrez]
PHST- 2013/07/03 06:00 [pubmed]
PHST- 2014/05/06 06:00 [medline]
AID - 1009-2137 (2013)03-0688-04 [pii]
AID - 10.7534/j.issn.1009-2137.2013.03.030 [doi]
PST - ppublish
SO  - Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2013 Jun;21(3):688-91. doi: 
      10.7534/j.issn.1009-2137.2013.03.030.