PMID- 23817305
OWN - NLM
STAT- MEDLINE
DCOM- 20131112
LR  - 20140628
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Linking)
VI  - 162
IP  - 1
DP  - 2013
TI  - Anisakis allergy component-resolved diagnosis: clinical and immunologic 
      differences between patients from Italy and Spain.
PG  - 39-44
LID - 10.1159/000351056 [doi]
AB  - BACKGROUND: Anisakissimplex is the main organism responsible for the zoonotic 
      disease anisakiasis which follows the ingestion of live larvae present in raw or 
      undercooked marine fish. Clinical features include severe epigastric pain, 
      frequently accompanied by severe allergic reactions. We investigated the 
      prevalence of immunoglobulin E (IgE) specific for 5 Anisakis allergens in Italian 
      patients sensitized or allergic to the parasite. The results were compared with 
      those obtained previously in a similar Spanish population. PATIENTS AND METHODS: 
      We conducted a descriptive, cross-sectional validation study. Asymptomatic 
      Anisakis-sensitized subjects (15 Italian and 17 Spanish) and Anisakis 
      allergic-patients (42 Italian and 35 Spanish) were studied by ImmunoCAP, 
      Western-blotting with nAni s 4 and dot-blotting with rAni s 1, rAni s 5, rAni s 9 
      and rAni s 10. RESULTS: Anisakis IgE CAP classes 1 or 2 were associated with a 
      high probability of asymptomatic sensitization (66.7%) while CAP classes 4 or 
      above, were associated with a very high probability of allergy to Anisakis 
      (95.2%). The most frequently detected allergen among Italian and Spanish allergic 
      patients was Ani s 1. All of the Spanish patients versus 76.2% of the Italian 
      patients recognized at least one of the allergens tested. Patients suffering from 
      gastrointestinal symptoms only were significantly more frequent among the 
      Italians whereas the Spanish presented more frequently with urticaria, angioedema 
      or anaphylaxis. CONCLUSIONS: Anisakis hypersensitivity shows different 
      immunological patterns in different European countries. Allergen component 
      diagnosis might help us to better understand this complex entity. 
      Anisakis-specific IgE levels may have moderate prognostic significance.
CI  - Copyright (c) 2013 S. Karger AG, Basel.
FAU - Caballero, Maria Luisa
AU  - Caballero ML
AD  - Department of Immunology, Hospital Carlos III, Madrid, Spain.
FAU - Asero, Riccardo
AU  - Asero R
FAU - Antonicelli, Leonardo
AU  - Antonicelli L
FAU - Kamberi, Erilda
AU  - Kamberi E
FAU - Colangelo, Caterina
AU  - Colangelo C
FAU - Fazii, Paolo
AU  - Fazii P
FAU - de Burgos, Carmen
AU  - de Burgos C
FAU - Rodriguez-Perez, Rosa
AU  - Rodriguez-Perez R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130626
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (Allergens)
RN  - 0 (Antigens, Helminth)
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (Helminth Proteins)
RN  - 0 (troponin-like protein, Anisakis simplex)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
CIN - Int Arch Allergy Immunol. 2014;163(4):243-4. PMID: 24603096
MH  - Allergens/*immunology
MH  - Animals
MH  - Anisakis/*immunology
MH  - Antigens, Helminth/immunology
MH  - Blotting, Western
MH  - Calcium-Binding Proteins/immunology
MH  - Cross-Sectional Studies
MH  - Food Hypersensitivity/immunology
MH  - Helminth Proteins/immunology
MH  - Humans
MH  - Hypersensitivity/immunology
MH  - Immunoblotting
MH  - Immunoglobulin E/immunology
MH  - Italy
MH  - Spain
EDAT- 2013/07/03 06:00
MHDA- 2013/11/13 06:00
CRDT- 2013/07/03 06:00
PHST- 2013/01/11 00:00 [received]
PHST- 2013/03/27 00:00 [accepted]
PHST- 2013/07/03 06:00 [entrez]
PHST- 2013/07/03 06:00 [pubmed]
PHST- 2013/11/13 06:00 [medline]
AID - 000351056 [pii]
AID - 10.1159/000351056 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2013;162(1):39-44. doi: 10.1159/000351056. Epub 2013 
      Jun 26.