PMID- 23817569
OWN - NLM
STAT- MEDLINE
DCOM- 20131017
LR  - 20220409
IS  - 1546-1718 (Electronic)
IS  - 1061-4036 (Print)
IS  - 1061-4036 (Linking)
VI  - 45
IP  - 8
DP  - 2013 Aug
TI  - A genome-wide association meta-analysis of self-reported allergy identifies 
      shared and allergy-specific susceptibility loci.
PG  - 907-11
LID - 10.1038/ng.2686 [doi]
AB  - Allergic disease is very common and carries substantial public-health burdens. We 
      conducted a meta-analysis of genome-wide associations with self-reported cat, 
      dust-mite and pollen allergies in 53,862 individuals. We used generalized 
      estimating equations to model shared and allergy-specific genetic effects. We 
      identified 16 shared susceptibility loci with association P<5x10(-8), including 8 
      loci previously associated with asthma, as well as 4p14 near TLR1, TLR6 and TLR10 
      (rs2101521, P=5.3x10(-21)); 6p21.33 near HLA-C and MICA (rs9266772, 
      P=3.2x10(-12)); 5p13.1 near PTGER4 (rs7720838, P=8.2x10(-11)); 2q33.1 in PLCL1 
      (rs10497813, P=6.1x10(-10)), 3q28 in LPP (rs9860547, P=1.2x10(-9)); 20q13.2 in 
      NFATC2 (rs6021270, P=6.9x10(-9)), 4q27 in ADAD1 (rs17388568, P=3.9x10(-8)); and 
      14q21.1 near FOXA1 and TTC6 (rs1998359, P=4.8x10(-8)). We identified one locus 
      with substantial evidence of differences in effects across allergies at 6p21.32 
      in the class II human leukocyte antigen (HLA) region (rs17533090, P=1.7x10(-12)), 
      which was strongly associated with cat allergy. Our study sheds new light on the 
      shared etiology of immune and autoimmune disease.
FAU - Hinds, David A
AU  - Hinds DA
AD  - 23andMe, Inc., Mountain View, California, USA. dhinds@23andMe.com
FAU - McMahon, George
AU  - McMahon G
FAU - Kiefer, Amy K
AU  - Kiefer AK
FAU - Do, Chuong B
AU  - Do CB
FAU - Eriksson, Nicholas
AU  - Eriksson N
FAU - Evans, David M
AU  - Evans DM
FAU - St Pourcain, Beate
AU  - St Pourcain B
FAU - Ring, Susan M
AU  - Ring SM
FAU - Mountain, Joanna L
AU  - Mountain JL
FAU - Francke, Uta
AU  - Francke U
FAU - Davey-Smith, George
AU  - Davey-Smith G
FAU - Timpson, Nicholas J
AU  - Timpson NJ
FAU - Tung, Joyce Y
AU  - Tung JY
LA  - eng
GR  - MC_UU_12013/3/MRC_/Medical Research Council/United Kingdom
GR  - 092731/WT_/Wellcome Trust/United Kingdom
GR  - R43 HL115873/HL/NHLBI NIH HHS/United States
GR  - MC_UU_12013/4/MRC_/Medical Research Council/United Kingdom
GR  - G9815508/MRC_/Medical Research Council/United Kingdom
GR  - 74882/MRC_/Medical Research Council/United Kingdom
GR  - 1R43HL115873-01/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130630
PL  - United States
TA  - Nat Genet
JT  - Nature genetics
JID - 9216904
RN  - 0 (Allergens)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Allergens/immunology
MH  - Animals
MH  - Cats
MH  - Cohort Studies
MH  - Female
MH  - *Genetic Loci
MH  - *Genetic Predisposition to Disease
MH  - *Genome-Wide Association Study
MH  - Humans
MH  - Hypersensitivity/*genetics/immunology
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Pyroglyphidae/immunology
MH  - Self Report
MH  - Young Adult
PMC - PMC3753407
MID - NIHMS489582
COIS- Competing Financial Interests D.A.H., A.K.K, C.B.D., N.E., J.L.M., U.F., and 
      J.Y.T. are current or former employees of, and own stock or stock options in, 
      23andMe, Inc.
EDAT- 2013/07/03 06:00
MHDA- 2013/10/18 06:00
PMCR- 2014/02/01
CRDT- 2013/07/03 06:00
PHST- 2012/10/29 00:00 [received]
PHST- 2013/06/05 00:00 [accepted]
PHST- 2013/07/03 06:00 [entrez]
PHST- 2013/07/03 06:00 [pubmed]
PHST- 2013/10/18 06:00 [medline]
PHST- 2014/02/01 00:00 [pmc-release]
AID - ng.2686 [pii]
AID - 10.1038/ng.2686 [doi]
PST - ppublish
SO  - Nat Genet. 2013 Aug;45(8):907-11. doi: 10.1038/ng.2686. Epub 2013 Jun 30.