PMID- 23817697
OWN - NLM
STAT- MEDLINE
DCOM- 20131031
LR  - 20211021
IS  - 1432-1335 (Electronic)
IS  - 0171-5216 (Linking)
VI  - 139
IP  - 9
DP  - 2013 Sep
TI  - Differential expression of microRNAs in plasma of patients with laryngeal 
      squamous cell carcinoma: potential early-detection markers for laryngeal squamous 
      cell carcinoma.
PG  - 1499-506
LID - 10.1007/s00432-013-1469-2 [doi]
AB  - PURPOSE: Altered microRNA (miRNA) expression has been found in many cancers, 
      including lung, breast, prostate, bladder and colorectal cancer. Many recent 
      studies have demonstrated that aberrant plasma miRNAs were also found in various 
      types of cancers. However, the alteration in plasma miRNA expressions in 
      laryngeal squamous cell carcinoma (LSCC) remains unclear. The present study aimed 
      to investigate the alterations in plasma miRNAs in LSCC. METHODS: In the present 
      study, the expression profiles of 738 miRNAs in plasma from 20 patients and 44 
      healthy subjects were evaluated using high-throughput real-time quantitative 
      polymerase chain reaction. RESULTS: Our results demonstrated that expression 
      levels of 17 miRNAs were significantly upregulated in patients with LSCCs when 
      compared to control group (p < 0.05). Expression levels of nine miRNAs were found 
      significantly downregulated in LSCC patients (p < 0.05). In addition, 17 miRNAs 
      were expressed only in LSCC group, and five of these miRNAs (miR-331-3p, 603, 
      1303, 660-5p and 212-3p) are LSCC specific and never seen before in plasma of any 
      human subject. CONCLUSION: In conclusion, our study suggests that detecting these 
      LSCC-specific miRNAs in plasma might serve as novel noninvasive biomarkers for 
      LSCC.
FAU - Ayaz, Lokman
AU  - Ayaz L
AD  - Department of Biochemistry, Faculty of Pharmacy, Trakya University, Edirne, 
      22030, Turkey. lokmanayaz@yahoo.com
FAU - Gorur, Aysegul
AU  - Gorur A
FAU - Yaroglu, Hatice Yildirim
AU  - Yaroglu HY
FAU - Ozcan, Cengiz
AU  - Ozcan C
FAU - Tamer, Lulufer
AU  - Tamer L
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130702
PL  - Germany
TA  - J Cancer Res Clin Oncol
JT  - Journal of cancer research and clinical oncology
JID - 7902060
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/blood/*genetics
MH  - Carcinoma, Squamous Cell/blood/diagnosis/*genetics
MH  - Case-Control Studies
MH  - Early Diagnosis
MH  - Female
MH  - Gene Expression Profiling
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Laryngeal Neoplasms/blood/diagnosis/*genetics
MH  - Male
MH  - MicroRNAs/*genetics
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Oligonucleotide Array Sequence Analysis
MH  - Prognosis
MH  - Real-Time Polymerase Chain Reaction
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Young Adult
EDAT- 2013/07/03 06:00
MHDA- 2013/11/01 06:00
CRDT- 2013/07/03 06:00
PHST- 2013/05/01 00:00 [received]
PHST- 2013/06/20 00:00 [accepted]
PHST- 2013/07/03 06:00 [entrez]
PHST- 2013/07/03 06:00 [pubmed]
PHST- 2013/11/01 06:00 [medline]
AID - 10.1007/s00432-013-1469-2 [doi]
PST - ppublish
SO  - J Cancer Res Clin Oncol. 2013 Sep;139(9):1499-506. doi: 
      10.1007/s00432-013-1469-2. Epub 2013 Jul 2.