PMID- 23818036
OWN - NLM
STAT- MEDLINE
DCOM- 20140213
LR  - 20130705
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Linking)
VI  - 8
IP  - 2
DP  - 2013 Aug
TI  - Effect of multivitamins on plasma homocysteine in patients with the 5,10 
      methylenetetrahydrofolate reductase C677T homozygous state.
PG  - 609-12
LID - 10.3892/mmr.2013.1563 [doi]
AB  - The role of hyperhomocysteinemia (HHcy) as a cardiovascular risk factor remains a 
      matter of debate, while it correlates with folates, it demonstrates inverse 
      correlation with plasma homocysteine (Hcy) levels and vitamin B12 levels and 
      reduces plasma Hcy levels following supplementation with multivitamins. The 
      purpose of this study was to demonstrate that administering multivitamins at 
      specific doses for 90 days restores normal plasma Hcy levels in women who are 
      homozygous for the thermolabile variant of 5,10 methylenetetrahydrofolate 
      reductase (MTHFR C677T). We enrolled 106 healthy females aged between 30 and 42 
      years, who were non-smokers, non-vegetarian, normotensive and who had no history 
      of food abuse in the previous months. Only females were enrolled in order to rule 
      out any bias due to the variation in Hcy plasma concentrations between males and 
      females. Patient blood sampling was performed in order to determine plasma Hcy, 
      serum folic acid and vitamin B12 levels. Furthermore, molecular characterization 
      of the C677T polymorphism present in the MTHFR gene, was also performed. The 
      results of this study demonstrated that supplementation with specific 
      multivitamins restores normal plasma Hcy levels, regardless of the MTHFR 
      genotype. Furthermore, it is unnecessary to adminster high doses of folate to 
      reduce plasma Hcy levels, and administering high doses of folate may cause 
      pro-inflammatory and pro-proliferative effects.
FAU - Dell'edera, Domenico
AU  - Dell'edera D
AD  - Unit of Cytogenetic and Molecular Genetics, Madonna delle Grazie Hospital, 
      Matera, Italy. domenicodelledera68@gmail.com
FAU - Tinelli, Andrea
AU  - Tinelli A
FAU - Milazzo, Giusi Natalia
AU  - Milazzo GN
FAU - Malvasi, Antonio
AU  - Malvasi A
FAU - Domenico, Carone
AU  - Domenico C
FAU - Pacella, Elena
AU  - Pacella E
FAU - Pierluigi, Compagnoni
AU  - Pierluigi C
FAU - Giuseppe, Tarantino
AU  - Giuseppe T
FAU - Marcello, Guido
AU  - Marcello G
FAU - Francesco, Lomurno
AU  - Francesco L
FAU - Epifania, Annunziata Anna
AU  - Epifania AA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130628
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
RN  - 0 (Vitamins)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 935E97BOY8 (Folic Acid)
RN  - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
RN  - P6YC3EG204 (Vitamin B 12)
SB  - IM
MH  - Adult
MH  - Female
MH  - Folic Acid/blood
MH  - Homocysteine/blood/*metabolism
MH  - *Homozygote
MH  - Humans
MH  - Hyperhomocysteinemia/drug therapy/genetics/metabolism
MH  - Methylenetetrahydrofolate Reductase (NADPH2)/*genetics/metabolism
MH  - *Mutation
MH  - Vitamin B 12/blood
MH  - Vitamins/*pharmacology/therapeutic use
EDAT- 2013/07/03 06:00
MHDA- 2014/02/14 06:00
CRDT- 2013/07/03 06:00
PHST- 2013/02/24 00:00 [received]
PHST- 2013/06/20 00:00 [accepted]
PHST- 2013/07/03 06:00 [entrez]
PHST- 2013/07/03 06:00 [pubmed]
PHST- 2014/02/14 06:00 [medline]
AID - 10.3892/mmr.2013.1563 [doi]
PST - ppublish
SO  - Mol Med Rep. 2013 Aug;8(2):609-12. doi: 10.3892/mmr.2013.1563. Epub 2013 Jun 28.