PMID- 23818496
OWN - NLM
STAT- MEDLINE
DCOM- 20140131
LR  - 20240322
IS  - 1943-0264 (Electronic)
IS  - 1943-0264 (Linking)
VI  - 5
IP  - 7
DP  - 2013 Jul 1
TI  - MET: a critical player in tumorigenesis and therapeutic target.
LID - 10.1101/cshperspect.a009209 [doi]
LID - a009209
AB  - Since its discovery more than 25 years ago, numerous studies have established 
      that the MET receptor is unique among tyrosine kinases. Signaling through MET is 
      necessary for normal development and for the progression of a wide range of human 
      cancers. MET activation has been shown to drive numerous signaling pathways; 
      however, it is not clear how MET signaling mediates diverse cellular responses 
      such as motility, invasion, growth, and angiogenesis. Great strides have been 
      made in understanding the pleotropic aspects of MET signaling using 
      three-dimensional molecular structures, cell culture systems, human tumors, and 
      animal models. These combined approaches have driven the development of 
      MET-targeted therapeutics that have shown promising results in the clinic. Here 
      we examine the unique features of MET and hepatocyte growth factor/scatter factor 
      (HGF/SF) structure and signaling, mutational activation, genetic mouse models of 
      MET and HGF/SF, and MET-targeted therapeutics.
FAU - Graveel, Carrie R
AU  - Graveel CR
AD  - Molecular Oncology, Van Andel Research Institute, Grand Rapids, Michigan 49503, 
      USA.
FAU - Tolbert, David
AU  - Tolbert D
FAU - Vande Woude, George F
AU  - Vande Woude GF
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20130701
PL  - United States
TA  - Cold Spring Harb Perspect Biol
JT  - Cold Spring Harbor perspectives in biology
JID - 101513680
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
SB  - IM
MH  - Animals
MH  - *Carcinogenesis
MH  - Gene Expression Regulation, Neoplastic
MH  - Hepatocyte Growth Factor/metabolism
MH  - Humans
MH  - Mice
MH  - Models, Biological
MH  - Mutation
MH  - Neoplasms/genetics/metabolism
MH  - Protein Structure, Tertiary
MH  - Proto-Oncogene Proteins c-met/chemistry/genetics/*physiology
MH  - Signal Transduction
PMC - PMC3685898
EDAT- 2013/07/03 06:00
MHDA- 2014/02/01 06:00
PMCR- 2015/07/01
CRDT- 2013/07/03 06:00
PHST- 2013/07/03 06:00 [entrez]
PHST- 2013/07/03 06:00 [pubmed]
PHST- 2014/02/01 06:00 [medline]
PHST- 2015/07/01 00:00 [pmc-release]
AID - 5/7/a009209 [pii]
AID - a009209 [pii]
AID - 10.1101/cshperspect.a009209 [doi]
PST - epublish
SO  - Cold Spring Harb Perspect Biol. 2013 Jul 1;5(7):a009209. doi: 
      10.1101/cshperspect.a009209.