PMID- 23818909
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130708
LR  - 20211021
IS  - 1687-9686 (Print)
IS  - 1687-9694 (Electronic)
IS  - 1687-9686 (Linking)
VI  - 2013
DP  - 2013
TI  - HLA-B *44 Is Associated with Dengue Severity Caused by DENV-3 in a Brazilian 
      Population.
PG  - 648475
LID - 10.1155/2013/648475 [doi]
LID - 648475
AB  - Human leukocyte antigen (HLA) alleles have been correlated with susceptibility or 
      resistance to severe dengue; however, few immunogenetic studies have been 
      performed in Latin American (LA) populations. We have conducted immunogenetic 
      studies of HLA class I and II alleles in a cohort of 187 patients with DENV-3 
      infection and confirmed clinical diagnosis of either severe dengue, known as 
      dengue hemorrhagic fever (DHF), or the less severe form, dengue fever (DF), in 
      Recife, Pernambuco, Brazil. An association analysis was performed using Fisher's 
      association test, with odds ratios (ORs) calculated using conditional maximum 
      likelihood estimates. HLA-B *44 (P = 0.047, OR = 2.025, 95% CI = 0.97-4.24) was 
      found to be associated with increased susceptibility to DHF in response to DENV-3 
      infection. In addition, HLA-B *07 (P = 0.048, OR = 0.501, one-sided 95% CI = 
      0-0.99) and HLA-DR *13 (P = 0.028, OR = 0.511, one-sided 95% CI = 0-0.91) were 
      found to be associated with resistance to secondary dengue infection by DENV-3. 
      These results suggest that HLA-B *44 supertype alleles and their respective T-cell 
      responses might be involved in susceptibility to severe dengue infections, 
      whereas the HLA-B *07 supertype alleles and DR *13 might be involved in 
      cross-dengue serotype immunity.
FAU - Xavier Eurico de Alencar, Liciana
AU  - Xavier Eurico de Alencar L
AD  - Virology and Experimental Therapy Laboratory, Aggeu Magalhaes Research Center, 
      Fiocruz, Avenida Moraes Rego s/n, Campus da UFPE, Cidade Universitaria, 50670-420 
      Recife, PE, Brazil.
FAU - de Mendonca Braga-Neto, Ulisses
AU  - de Mendonca Braga-Neto U
FAU - Jose Moura do Nascimento, Eduardo
AU  - Jose Moura do Nascimento E
FAU - Tenorio Cordeiro, Marli
AU  - Tenorio Cordeiro M
FAU - Maria Silva, Ana
AU  - Maria Silva A
FAU - Alexandre Antunes de Brito, Carlos
AU  - Alexandre Antunes de Brito C
FAU - da Silva, Maria da Paz Carvalho
AU  - da Silva Mda P
FAU - Gil, Laura Helena Vega Gonzales
AU  - Gil LH
FAU - Montenegro, Silvia Maria Lucena
AU  - Montenegro SM
FAU - Marques, Ernesto Torres de Azevedo Jr
AU  - Marques ET Jr
LA  - eng
GR  - U19 AI056541/AI/NIAID NIH HHS/United States
PT  - Journal Article
DEP - 20130602
PL  - Egypt
TA  - J Trop Med
JT  - Journal of tropical medicine
JID - 101524194
PMC - PMC3684019
EDAT- 2013/07/03 06:00
MHDA- 2013/07/03 06:01
PMCR- 2013/06/02
CRDT- 2013/07/03 06:00
PHST- 2013/01/31 00:00 [received]
PHST- 2013/04/11 00:00 [revised]
PHST- 2013/04/15 00:00 [accepted]
PHST- 2013/07/03 06:00 [entrez]
PHST- 2013/07/03 06:00 [pubmed]
PHST- 2013/07/03 06:01 [medline]
PHST- 2013/06/02 00:00 [pmc-release]
AID - 10.1155/2013/648475 [doi]
PST - ppublish
SO  - J Trop Med. 2013;2013:648475. doi: 10.1155/2013/648475. Epub 2013 Jun 2.